Respiratory Pharmacology Questions and Answers (Q&A)

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Why Theophylline is consider to wrong ,isn't it from xanthine which consider to be a type of bronchodilators ?

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Hypokalemia

The Pharmacology of B2-Adrenoceptor Agonists Chemistry o Chemical derivatives of the catecholamines norepinephrine and epinephrine o Levalbuterol is the R-isomer of albuterol; arformoterol is the R,R-isomer of formoterol Pharmacokinetics o Oral, parenteral, and...
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Concomitant zileuton treatment -theophylline (elixophyllin®; theo-24®) aminophylline chemistry o related to the compound caffeine o theophylline: 1,3-dimethylxanthine o aminophylline: theophylline-ethylenediamine complex salt form that has increased solubility at neutral ph ...Read More

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Relax bronchial constriction caused by parasympathetic stimulation
2. Inhibits augmentation of mucous secretion
3. Increases the mucocillary clearance of bronchial secretions

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B2-adrenoceptor agonists - theophylline / muscarinic receptor agonists - cysteinyl-leukotriene receptor antagonists

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Orally
Act on the cysteinyl-leukotriene receptors, causing bronchodilatation, and preventing aspirin-sensitive and exercise-induced asthma and reducing sputum eosinophilia

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Decrease the formation of cytokines, in particular the Th2 cytokines and decrease eosinophilic recruitment and activation
Decrease IgE production and IgE receptor expression and inhibit vasodilatation by suppressing PGE2 and PGI2 though induction of COX-2
Decrease spasmogens LTC4 and...
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Slowly adapting stretch receptors
Unmyelinated senory C fibres
Rapidly adapting irritant receptors associated with myelinated vagal fibres

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Mediate contraction of brachial smooth muscle and secretion of glands

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