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Answer updated on: 12 Feb 2020
All of the above(E) is the correct answer here. All of the above are concerns regarding statins.
AST/ALT elevations are indicators of liver toxicity. This is very rare but it can occur. The levels of these enzymes are based on upper limit of normal (ULN). If a patient is 50x normal, there is a problem. This is known as rhabdomyolysis. Skeletal muscle cells break down so much that acute ...
Answer updated on: 12 Feb 2020
Fluvastatin(B) is the correct answer here. Fluvastatin is metabolized by 2C9.
The point of this question is to understand that three statins: simvastatin, atorvastatin, and lovastatin, are metabolized by 3A4. 40% of drugs have some sort of interaction (metabolized, inducer, inhibitor) with 3A4 and makes the interaction relevant. For instance, the HIV protease inhibitor, ritonavir, is one of ...
Answer updated on: 12 Feb 2020
80 mg qhs should be the start dose in every patient(D) is the false statement. 80 mg qhs is dangerous. The risks of adverse effects, such as myopathy are quite great. this dosage is reserved for those who have been taking it that high for at least 1 year. It shouldnt be the starting dose.
(A) is true. Azole antifungals (fluconazole, itraconazole) are potent inhibitors of CYP enzymes. They are ...
Answer updated on: 12 Feb 2020
It is synergistic with statins for LDL-lowering effects(E) is the correct answer. All of the above are true regarding ezetimibe. The following will explain why that is the case.
(A) is true, as mentioned before. The combination effect of these two drug classes will help decrease teh compensatory cholesterol synthesis by the liver due to the loss of cholesterol from ezetimibe. The synergistic ...
Answer updated on: 12 Feb 2020
They are clinically proven to protect individuals from atherosclerosis(C) is the false statement. Omega-3 fatty acids are NOT proven to protect against atherosclerosis. The outcome studies are lacking and the evidence is not yet convincing.
(A) is true. that is one of the hallmarks of these drugs. The lowering effect is on par with fibrates and niacin (30-40%). There are no changes to a ...
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