Pharmacology Drug Metabolism

20 Questions  I  By Pharmdnate on February 19, 2011
Drug Metabolism quiz.

  
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Question Excerpt

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1.  What does lack of UDP-glucuronosyl transferase cause?
A.
B.
C.
D.
E.
2.  What is the antidote for acetaminophen overdose to protect patients from hepatotoxicity and death?
A.
B.
C.
D.
E.
3.  What drug after phase 2 results in a more active metabolite?
A.
B.
C.
D.
E.
4.  What drug's metabolism has phase 2 preceding phase 1?
A.
B.
C.
D.
E.
5.  What enzyme will methanol and ethanol both compete for?
A.
B.
C.
D.
E.
6.  What usually functions to expel drugs from the intestinal mucosa into the lumen?
A.
B.
C.
D.
E.
7.  Which of the following is induces enzymes in the liver and lungs?
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B.
C.
D.
E.
8.  How can a women on hormonal contraceptives become pregnant?
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B.
C.
D.
9.  Who may have prolonged or toxic reponses to normal doses of that drug?
A.
B.
C.
D.
E.
10.  What is the mechanism by which the body terminates the action of some drugs and also serves to activate prodrugs?
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B.
C.
D.
E.
11.  What is resonsible for conjugating bilirubin in the liver and facilitating its excretion?
A.
B.
C.
D.
E.
12.  What drugs are metabolized to products that irreversibly inhibit the metabolizing?
A.
B.
C.
D.
E.
13.  Which of the following will treat neonatal jaundice?
A.
B.
C.
D.
E.
14.  What phase 1 reaction is mainly performed by the cytochrome P450 enzymes also called mixed-function enzymes?
A.
B.
C.
15.  Which of the following is known to inhibit the CYP3A4 metabolism and P-glycoprotein in the small intestine?
A.
B.
C.
D.
E.
16.  An inducer will cause what to happen?
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B.
C.
D.
E.
17.  What induces UDP-glucuronosyl tranferase?
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B.
C.
D.
E.
18.  Oxidation of ethanol, estrogens, benzodiazepines and salicylates in women is what compared to men?
A.
B.
C.
D.
19.  Which of the following is an antiepileptic drug that induces CYP3A4 and is also metabolized by CYP3A4?
A.
B.
C.
D.
E.
20.  Which of the followinf is an antifungal drug that binds to P450 enzymes causing competitive inhibition?
A.
B.
C.
D.
E.
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