Pharmacology Drug Metabolism

20 Questions  I  By Pharmdnate
Drug Metabolism quiz.

  
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1.  Which of the following is known to inhibit the CYP3A4 metabolism and P-glycoprotein in the small intestine?
A.
B.
C.
D.
E.
2.  Which of the following is an antiepileptic drug that induces CYP3A4 and is also metabolized by CYP3A4?
A.
B.
C.
D.
E.
3.  Which of the following will treat neonatal jaundice?
A.
B.
C.
D.
E.
4.  What is the mechanism by which the body terminates the action of some drugs and also serves to activate prodrugs?
A.
B.
C.
D.
E.
5.  Oxidation of ethanol, estrogens, benzodiazepines and salicylates in women is what compared to men?
A.
B.
C.
D.
6.  What drug after phase 2 results in a more active metabolite?
A.
B.
C.
D.
E.
7.  What enzyme will methanol and ethanol both compete for?
A.
B.
C.
D.
E.
8.  What induces UDP-glucuronosyl tranferase?
A.
B.
C.
D.
E.
9.  What does lack of UDP-glucuronosyl transferase cause?
A.
B.
C.
D.
E.
10.  Who may have prolonged or toxic reponses to normal doses of that drug?
A.
B.
C.
D.
E.
11.  What drugs are metabolized to products that irreversibly inhibit the metabolizing?
A.
B.
C.
D.
E.
12.  An inducer will cause what to happen?
A.
B.
C.
D.
E.
13.  Which of the following is induces enzymes in the liver and lungs?
A.
B.
C.
D.
E.
14.  What drug's metabolism has phase 2 preceding phase 1?
A.
B.
C.
D.
E.
15.  What is resonsible for conjugating bilirubin in the liver and facilitating its excretion?
A.
B.
C.
D.
E.
16.  What phase 1 reaction is mainly performed by the cytochrome P450 enzymes also called mixed-function enzymes?
A.
B.
C.
17.  Which of the followinf is an antifungal drug that binds to P450 enzymes causing competitive inhibition?
A.
B.
C.
D.
E.
18.  What usually functions to expel drugs from the intestinal mucosa into the lumen?
A.
B.
C.
D.
E.
19.  What is the antidote for acetaminophen overdose to protect patients from hepatotoxicity and death?
A.
B.
C.
D.
E.
20.  How can a women on hormonal contraceptives become pregnant?
A.
B.
C.
D.
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