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Pharmacology Drug Metabolism

20 Questions  I  By Pharmdnate
Pharmacology Drug Metabolism
Drug Metabolism quiz.

  
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Question Excerpt

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1.  What phase 1 reaction is mainly performed by the cytochrome P450 enzymes also called mixed-function enzymes?
A.
B.
C.
2.  What induces UDP-glucuronosyl tranferase?
A.
B.
C.
D.
E.
3.  What enzyme will methanol and ethanol both compete for?
A.
B.
C.
D.
E.
4.  What drug after phase 2 results in a more active metabolite?
A.
B.
C.
D.
E.
5.  Who may have prolonged or toxic reponses to normal doses of that drug?
A.
B.
C.
D.
E.
6.  Which of the followinf is an antifungal drug that binds to P450 enzymes causing competitive inhibition?
A.
B.
C.
D.
E.
7.  Which of the following is known to inhibit the CYP3A4 metabolism and P-glycoprotein in the small intestine?
A.
B.
C.
D.
E.
8.  What is the antidote for acetaminophen overdose to protect patients from hepatotoxicity and death?
A.
B.
C.
D.
E.
9.  What does lack of UDP-glucuronosyl transferase cause?
A.
B.
C.
D.
E.
10.  What is the mechanism by which the body terminates the action of some drugs and also serves to activate prodrugs?
A.
B.
C.
D.
E.
11.  What usually functions to expel drugs from the intestinal mucosa into the lumen?
A.
B.
C.
D.
E.
12.  Which of the following is induces enzymes in the liver and lungs?
A.
B.
C.
D.
E.
13.  What drugs are metabolized to products that irreversibly inhibit the metabolizing?
A.
B.
C.
D.
E.
14.  What drug's metabolism has phase 2 preceding phase 1?
A.
B.
C.
D.
E.
15.  Which of the following will treat neonatal jaundice?
A.
B.
C.
D.
E.
16.  Which of the following is an antiepileptic drug that induces CYP3A4 and is also metabolized by CYP3A4?
A.
B.
C.
D.
E.
17.  An inducer will cause what to happen?
A.
B.
C.
D.
E.
18.  How can a women on hormonal contraceptives become pregnant?
A.
B.
C.
D.
19.  What is resonsible for conjugating bilirubin in the liver and facilitating its excretion?
A.
B.
C.
D.
E.
20.  Oxidation of ethanol, estrogens, benzodiazepines and salicylates in women is what compared to men?
A.
B.
C.
D.
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