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Pharmacology Drug Metabolism

20 Questions  I  106 Attempts  I  Created By pharmdnate 823 days ago
Drug Metabolism quiz.
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Question Excerpt From Pharmacology Drug Metabolism
Q.1) 

What is the mechanism by which the body terminates the action of some drugs and also serves to activate prodrugs?
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Q.2)  What phase 1 reaction is mainly performed by the cytochrome P450 enzymes also called mixed-function enzymes?
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Q.3)  What drug's metabolism has phase 2 preceding phase 1?
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Q.4) 

What drug after phase 2 results in a more active metabolite?
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Q.5)  What is resonsible for conjugating bilirubin in the liver and facilitating its excretion?
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Q.6)  What does lack of UDP-glucuronosyl transferase cause?
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Q.7)  What induces UDP-glucuronosyl tranferase?
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Q.8) 

An inducer will cause what to happen?
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Q.9)  What drugs are metabolized to products that irreversibly inhibit the metabolizing?
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Q.10)  What usually functions to expel drugs from the intestinal mucosa into the lumen?
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Q.11)  Oxidation of ethanol, estrogens, benzodiazepines and salicylates in women is what compared to men?
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Q.12) 

Which of the following is known to inhibit the CYP3A4 metabolism and P-glycoprotein in the small intestine?
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Q.13) 

Which of the following is induces enzymes in the liver and lungs?
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Q.14)  How can a women on hormonal contraceptives become pregnant?
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Q.15) 

What enzyme will methanol and ethanol both compete for?
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Q.16) 

What is the antidote for acetaminophen overdose to protect patients from hepatotoxicity and death?
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Q.17) 

Which of the following will treat neonatal jaundice?
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Q.18)  Who may have prolonged or toxic reponses to normal doses of that drug?
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Q.19)  Which of the following is an antiepileptic drug that induces CYP3A4 and is also metabolized by CYP3A4?
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Q.20) 

Which of the followinf is an antifungal drug that binds to P450 enzymes causing competitive inhibition?
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