Related Topics
Take Another Quiz

Pharmacology Drug Metabolism

20 Questions
Pharmacology Quizzes & Trivia

Drug Metabolism quiz.

Questions and Answers
  • 1. 
    • A. 

      Bioavailability

    • B. 

      Biotransformation

    • C. 

      Enzyme induction

    • D. 

      Enzyme inhibition

    • E. 

      None of the above

  • 2. 
    • A. 

      Hydrolysis

    • B. 

      Oxidation

    • C. 

      Reduction

  • 3. 
    • A. 

      Mitomycin C

    • B. 

      Ketoconazole

    • C. 

      Isoniazid

    • D. 

      Tamoxifen

    • E. 

      Morphine

  • 4. 
    What drug after phase 2 results in a more active metabolite?
    • A. 

      Mitomycin C

    • B. 

      Ketoconazole

    • C. 

      Isoniazid

    • D. 

      Ethanol

    • E. 

      Morphine

  • 5. 
    What is resonsible for conjugating bilirubin in the liver and facilitating its excretion?
    • A. 

      UDP-glucuronosyl transferase

    • B. 

      N-acetyltransferase

    • C. 

      Pseudocholinesterase

    • D. 

      Vitamin K epoxide reductase

    • E. 

      Alcohol dehydrogenase

  • 6. 
    • A. 

      Bilirubin encephalopathy

    • B. 

      Neonatal jaundice

    • C. 

      Kernicterus

    • D. 

      A and B

    • E. 

      All of the above

  • 7. 
    What induces UDP-glucuronosyl tranferase?
    • A. 

      Phototherapy

    • B. 

      Barbiturate phenobarbital

    • C. 

      N-acetylcysteine

    • D. 

      A and B

    • E. 

      All of the above

  • 8. 
    An inducer will cause what to happen?
    • A. 

      Increase the amount of isozymes and increase metabolism

    • B. 

      Decrease the amount of isozymes and increase metabolism

    • C. 

      Increase the amount of isozymes and decrease metabolism

    • D. 

      Decrease the amount of isozymes and decrease metabolism

    • E. 

      None of the above

  • 9. 
    What drugs are metabolized to products that irreversibly inhibit the metabolizing?
    • A. 

      CYP3A4 inhibitor

    • B. 

      Slow acetylators

    • C. 

      Suicide inhibitors

    • D. 

      P-gp inhibitors

    • E. 

      None of the above

  • 10. 
    What usually functions to expel drugs from the intestinal mucosa into the lumen?
    • A. 

      Single nucleotide polymorphism

    • B. 

      Slow acetylators

    • C. 

      Smoking

    • D. 

      P-glycoprotein

    • E. 

      Grapefriut juice

  • 11. 
    • A. 

      Increased

    • B. 

      Decreased

    • C. 

      The same

    • D. 

      Cannot be determined

  • 12. 
    Which of the following is known to inhibit the CYP3A4 metabolism and P-glycoprotein in the small intestine?
    • A. 

      Single nucleotide polymorphism

    • B. 

      Slow acetylators

    • C. 

      Smoking

    • D. 

      P-glycoprotein

    • E. 

      Grapefriut juice

  • 13. 
    Which of the following is induces enzymes in the liver and lungs?
    • A. 

      Single nucleotide polymorphism

    • B. 

      Slow acetylators

    • C. 

      Smoking

    • D. 

      P-glycoprotein

    • E. 

      Grapefriut juice

  • 14. 
    How can a women on hormonal contraceptives become pregnant?
    • A. 

      If she also takes a CYP3A4 inducer

    • B. 

      If she also takes a CYP3A4 inhibitor

    • C. 

      She cannot get pregnant

    • D. 

      Cannot predict

  • 15. 
    What enzyme will methanol and ethanol both compete for?
    • A. 

      UDP-glucuronosyl transferase

    • B. 

      N-acetyltransferase

    • C. 

      Pseudocholinesterase

    • D. 

      Vitamin K epoxide reductase

    • E. 

      Alcohol dehydrogenase

  • 16. 
    What is the antidote for acetaminophen overdose to protect patients from hepatotoxicity and death?
    • A. 

      Phototherapy

    • B. 

      Barbiturate phenobarbital

    • C. 

      N-acetylcysteine

    • D. 

      A and B

    • E. 

      All of the above

  • 17. 
    Which of the following will treat neonatal jaundice?
    • A. 

      Phototherapy

    • B. 

      Barbiturate phenobarbital

    • C. 

      N-acetylcysteine

    • D. 

      A and B

    • E. 

      All of the above

  • 18. 
    • A. 

      Slow acetylators

    • B. 

      Fast metabolizers

    • C. 

      Ultra metabolizers

    • D. 

      B and C

    • E. 

      All of the above

  • 19. 
    Which of the following is an antiepileptic drug that induces CYP3A4 and is also metabolized by CYP3A4?
    • A. 

      Ketoconazole

    • B. 

      Tamoxifen

    • C. 

      Carbamazepine

    • D. 

      Mitomycin C

    • E. 

      Losartan

  • 20. 
    Which of the followinf is an antifungal drug that binds to P450 enzymes causing competitive inhibition?
    • A. 

      Ketoconazole

    • B. 

      Tamoxifen

    • C. 

      Carbamazepine

    • D. 

      Mitomycin C

    • E. 

      Losartan