Mic 541 Exam 4 - Mycology I And II

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MIC 541 Exam 4 - Mycology I and II

  
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  • 1. 
    Fungi are a main cause of human infection.
    • A. 

      True

    • B. 

      False


  • 2. 
    Infections from fungi occur mostly due to:
    • A. 

      Disruption of natural barriers

    • B. 

      Immunosuppression

    • C. 

      Occupational contact

    • D. 

      All of the above


  • 3. 
    Fungi reproduce by which fo the following?
    • A. 

      Fission, as in bacteria

    • B. 

      Budding – mostly in yeasts

    • C. 

      Fragmentation of hyphae

    • D. 

      Spore formation by mold forms


  • 4. 
    Fungi that infect outside layers of skin or hair only are classified as?
    • A. 

      Superficial

    • B. 

      Cutaneous

    • C. 

      Subcutaneous

    • D. 

      Systemic

    • E. 

      Opportunistic


  • 5. 
    Fungi that invade skin, hair, nails are classified as?
    • A. 

      Superficial

    • B. 

      Cutaneous

    • C. 

      Subcutaneous

    • D. 

      Systemic

    • E. 

      Opportunistic


  • 6. 
    Fungi that are localized and enter by trauma are classified as?
    • A. 

      Superficial

    • B. 

      Cutaneous

    • C. 

      Subcutaneous

    • D. 

      Systemic

    • E. 

      Opportunistic


  • 7. 
    Fungi that are more virulent and cause disease in healthy hosts are classified as?
    • A. 

      Superficial

    • B. 

      Cutaneous

    • C. 

      Subcutaneous

    • D. 

      Systemic

    • E. 

      Opportunistic


  • 8. 
    Fungi that infect only infect compromised hosts are clasified as?
    • A. 

      Superficial

    • B. 

      Cutaneous

    • C. 

      Subcutaneous

    • D. 

      Systemic

    • E. 

      Opportunistic


  • 9. 
    Which part of the fungal cell should a drug target so as to cause the least amount of damage to the human host?
    • A. 

      Cholesterol in cell membrane

    • B. 

      Ergosterol in cell membrane

    • C. 

      Nucleus


  • 10. 
    Which antifungal drug binds to ergosterol in the fungal membrane and forms pores in the membrane?
    • A. 

      Amphotericin

    • B. 

      5-fluorocytosine

    • C. 

      Terbinafine

    • D. 

      The azoles

    • E. 

      Caspofungin


  • 11. 
    Amphotericin causes the cell to be leaky, which alters its permeability to which of the following?
    • A. 

      Mg

    • B. 

      Na

    • C. 

      Cl

    • D. 

      K


  • 12. 
    A person can only get a certain amount of Amphotercin in his/her lifetime.
    • A. 

      True

    • B. 

      False


  • 13. 
    Which drug do fungi take it up using a permease that our cells do not make.  It gets incorporated into the fungal RNA in place of uracil. 
    • A. 

      Amphotericin

    • B. 

      5-fluorocytosine

    • C. 

      Terbinafine

    • D. 

      The azoles

    • E. 

      Caspofungin


  • 14. 
    The fungal cells can develop a resistance to *this drug* if given by itself, so it is usually given in combination with Amphotericin B
    • A. 

      5-fluorocytosine

    • B. 

      Terbinafine

    • C. 

      The azoles

    • D. 

      Capsofungin


  • 15. 
    This drug is good for fungal meningitis since it can enter the CNS.
    • A. 

      Amphotericin

    • B. 

      5-fluorocytosine

    • C. 

      Terbinafine

    • D. 

      The azoles

    • E. 

      Capsofungin


  • 16. 
    Which antifungal drug Blocks squalene epoxidase enzyme to prevent squalene conversion to ergosterol. 
    • A. 

      Amphotericin

    • B. 

      5-flurocytosine

    • C. 

      Terbinafine

    • D. 

      The azoles

    • E. 

      Capsofungin


  • 17. 
    Which of the following are characteristic of terbinafine?
    • A. 

      Given orally

    • B. 

      Given topically

    • C. 

      Used to treat dermatophytes

    • D. 

      Used to treat nail infections


  • 18. 
    Which antifungal drug inhibits cytochromes (cytochrome P450)?  This prevents ergosterol formation, which disrupts membrane function and growth
    • A. 

      Amphotericin

    • B. 

      5-flurocytosine

    • C. 

      Terbinafine

    • D. 

      The azoles

    • E. 

      Capsofungin


  • 19. 
    Which antifungal drug can have the following side effects?males – may develop breastsfemales – irregular menstrual cyclesliver toxicity
    • A. 

      Amphotericin

    • B. 

      5-flurocytosine

    • C. 

      Terbinafine

    • D. 

      The azoles

    • E. 

      Capsofungin


  • 20. 
    Thiazoles have the same SE but are less toxic than imidazoles
    • A. 

      True

    • B. 

      False


  • 21. 
    Which antifungal drug Inhibits β-(1,3)-D-glucan synthesis, which usually makes the cross-bridges in the fungal cell wall.  Therefore cell wall formation is inhibited
    • A. 

      Amphotericin

    • B. 

      5-flurocytosine

    • C. 

      The azoles

    • D. 

      Terbinafine

    • E. 

      Capsofungin


  • 22. 
    Which of the following are Imidazoles that  are used as–topical replacements for nystatin 
    • A. 

      Ketoconazole

    • B. 

      Clotrimazole

    • C. 

      Miconazole

    • D. 

      Voriconazole


  • 23. 
    Fluconazole is used to treat meningitis, because it can attain good CNS levels
    • A. 

      True

    • B. 

      False


  • 24. 
    Echinocandins is a class of antifungals that act as a fungicidal for Candida and also work against Aspergillus
    • A. 

      True

    • B. 

      False


  • 25. 
    Nystatin is a polyene similar to Amphotericin B.
    • A. 

      True

    • B. 

      False


  • 26. 
    Which of the following are true about Pityriasis Versicolor?
    • A. 

      Chronic infection

    • B. 

      Superficial infection of outer skin

    • C. 

      Hypo- or hyperpigmented scaly lesions

    • D. 

      Can be treated by keratinolytic agents (salicylic acid)

    • E. 

      Can be treated by topical imidazoles (miconazole)


  • 27. 
    Which 3 genera are known as Dermatophytes
    • A. 

      Sporothrix sp

    • B. 

      Microsporum sp.

    • C. 

      Trichophyton sp.

    • D. 

      Epidermophyton sp

    • E. 

      Histoplasma sp.


  • 28. 
    Cutaneous Mycoses are also called Called tineas or ringworms
    • A. 

      True

    • B. 

      False


  • 29. 
    Which of the following are not correctly matched?
    • A. 

      Tinea corporis – hairy body parts

    • B. 

      Tinea capitis – scalp

    • C. 

      Tinea pedis – athlete’s foot

    • D. 

      Tinea barbae – beard

    • E. 

      Tinea cruris – jock itch

    • F. 

      Tinea unguium – jock itch


  • 30. 
    Which of the following shows up as typical “ringworm” lesions
    • A. 

      Tinea corporis

    • B. 

      Tinea capitis

    • C. 

      Tinea cruris

    • D. 

      Tinea unguium


  • 31. 
    Which of the following are true about treatment of tinea corporis?
    • A. 

      Topical treatment usually lasts 2-4 monthhs

    • B. 

      Miconazole is used topically

    • C. 

      Clotrimazole is used topically

    • D. 

      Treatment can be stopped as soon as clearing is noted

    • E. 

      Itraconazole and terbinafine can be used orally as needed


  • 32. 
    Which of the following is  mostly seen in children before puberty?
    • A. 

      Tinea corporis

    • B. 

      Tinea unguium

    • C. 

      Tinea cruris

    • D. 

      Tinea capitis


  • 33. 
    Which of the following is NOT true regarding treatment of tinea capitis?
    • A. 

      Only topical treatment is needed

    • B. 

      1-2 months

    • C. 

      Terbinafine cream

    • D. 

      Shampoo frequently with selinium sulfide

    • E. 

      Topical azoles


  • 34. 
    Tinea pedis is the most prevalent dermatophytosis in U.S.
    • A. 

      True

    • B. 

      False


  • 35. 
    Which of the following is a subcutaneous Mycosis known as “rose-handler’s” disease
    • A. 

      Cryptocococcosis

    • B. 

      Histoplasmosis

    • C. 

      Sporotrichosis

    • D. 

      Tinea cruris


  • 36. 
    Which of the following is the cause of sporotrichosis?
    • A. 

      Coccidioides immitis

    • B. 

      Sporothrix schenckii

    • C. 

      Cryptococcus neoformans

    • D. 

      Histoplasma capsulatum


  • 37. 
    Treat Sporotrichosis caused by  Sporothrix schenckii  with newer azole, e.g. itraconazole
    • A. 

      True

    • B. 

      False


  • 38. 
    What is the primary focus of infection for Systemic Mycoses
    • A. 

      Lung

    • B. 

      Heart

    • C. 

      Skin

    • D. 

      Liver


  • 39. 
    Which systemic mycosis is usually found in the oil of southwest U.S., Mexico, South America and is referred to as San Joaquin Valley Fever?
    • A. 

      Histoplasmosis

    • B. 

      Coccidioidomycosis

    • C. 

      Cryptocococcosis

    • D. 

      Blastomycosis


  • 40. 
    Which of the following is not true regarding Histoplasma capsulatum
    • A. 

      Most cases are in mid-western U.S.

    • B. 

      It is capsulated

    • C. 

      80% of people in Ohio, Mississippi River Valleys skin test positive

    • D. 

      Is the cause of Histoplasmosis

    • E. 

      Growth in soil stimulated by bird, bat dung


  • 41. 
    Which of the following is not dimorphic and is the only medically important encapsulated yeast?
    • A. 

      Histoplasma capsulatum

    • B. 

      Cryptococcus neoformans

    • C. 

      Coccidioides immitis


  • 42. 
     Histoplasmosis is the hallmark infection of AIDS patients
    • A. 

      True

    • B. 

      False


  • 43. 
    Cryptococcosis may mimic brain tumor, abscess, or MS
    • A. 

      True

    • B. 

      False


  • 44. 
    Which of the following is true regarding Cryptococcosis Treatment
    • A. 

      Not usually needed for pulmonary infection

    • B. 

      Mandatory for meningitis

    • C. 

      Amphotericin B i.v. ± 5-flurocytosine

    • D. 

      Sometimes can switch to oral azole

    • E. 

      All of the above are true


  • 45. 
    A diaper rash is also known as a candidiasis infection.
    • A. 

      True

    • B. 

      False


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