Final Exam 4

49 Questions  I  By Jaffryf
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1.  The enzyme that joins the Okazaki fragments of thelagging strand together into a continuous strand iscalled _______.
A.
B.
C.
D.
E.
2.  Why do the telomeres of dermis fibroblasts shorten afterthey have gone through many cell divisions?
A.
B.
C.
D.
E.
3.  You are studing a strain of bacteria that carries atemperature-sensitive mutation in one of the genesrequired for DNA replication. The bacteria grownormally at the lower temperature, but when thetemperature is raised they die. When you analyze theremains of the bacterial cells grown at the highertemperature you find evidence of partly replicatedDNA. When the strands of this DNA are separated byheating, numerous single-stranded DNA moleculesaround 1000 nucleotides long are found. Which proteinis most likely to be impaired in there mutant bacteria
A.
B.
C.
D.
E.
4.  The site on DNA to which RNA polymerases bindbefore initiating transcription is called the ______.
A.
B.
C.
D.
E.
5.  Why do dideoxi(dd)NTPs terminate chain growthduring DNA synthesis in DNA sequencing?
A.
B.
C.
D.
E.
6.  Which end of a microtubule is the slow growing end
A.
B.
C.
D.
E.
7.  Which protein below is often a component ofintermediate filaments?
A.
B.
C.
D.
E.
8.  The __-carbon of the sugar of a nucleotide participatesin the formation of the phosphodiester bond
A.
B.
C.
D.
E.
9.  What led Avery, MacLeod and McCarty to concludethat DNA was the transformation principle reported byGriffith and others?
A.
B.
C.
D.
E.
10.  Ring-shaped complexes in the centrosome contain________ in combination with ________
A.
B.
C.
D.
E.
11.  When microtubules grow out of a centrosome, whichend is oriented away from the centrosome?
A.
B.
C.
D.
12.  Taxol inhibits the disassembly of microtubules. Howdoes this harm the cells?
A.
B.
C.
D.
13.  To which end of microtubules are tubulin subunitsprimarily added in vitro?
A.
B.
C.
D.
E.
14.  A new antibiotic is able to bind the rho (ñ) factorassociated with some transcription processes; as aresult this antibiotic would affect
A.
B.
C.
D.
15.  If two DNA strands of identical length were analyzed,which of the following statements would be true of theirTm or melting temperature?
A.
B.
C.
D.
16.  Which DNA polymerase is mainly responsible forgenome replication in E. coli?
A.
B.
C.
D.
17.  Which one of the following proteins and enzymes donot function at the origin of replication in E. coli?
A.
B.
C.
D.
18.  Which enzyme in E. coli is responsible for relieving thetension ahead of the fork that results when the DNA isunwound to form the replication bubble or eye?
A.
B.
C.
D.
19.  What is the name of the thin sheetlike structures that acell (fibroblast) extends during crawling?
A.
B.
C.
D.
E.
20.  Which subunit of RNA polymerase establishestemplate binding to a promoter in prokaryotes?
A.
B.
C.
D.
21.  ___________bonds are responsible for the polymerbackbone of DNA, while ________ bonds primarilyaccount for complementary base pairing in DNA.
A.
B.
C.
D.
E.
22.  Meselson and Stahl allowed bacteria raised in 15Nmedium to replicate in 14N medium. At the end of tworounds of DNA replication, they observed ______band(s) in their centrifugation tubes which was/werecomposed of _______.
A.
B.
C.
D.
E.
23.  Why is an RNA primer considered essential for DNAsynthesis by DNA polymerase III?
A.
B.
C.
D.
24.  End-blocking or capping proteins __________.
A.
B.
C.
D.
E.
25.  What term refers to the fact that growing and shrinkingmicrotubles can coexist in the same cell region andthat a given microtubule can switch back and forthbetween growing and shortening?
A.
B.
C.
D.
E.
26.  Along which structure do membranous vesicles andorganelles typically engage in local movement in thecell periphery of an animal cell?
A.
B.
C.
D.
E.
27.  When the rate of loss of actin subunits from thepointed end of an actin filament is balanced by the rateof their addition to the barbed end, ____________.
A.
B.
C.
D.
E.
28.  ________ refers to the fact that the sequence of oneDNA strand specifies the sequence of the other strandin the double helix?
A.
B.
C.
D.
E.
29.  The current model for the nucleation of microtubules isthat a helical array of ã-tubulin subunit forms an open,ring-shaped template on which the first row of áâ-tubulin dimers assembles. How does this modelaccount for the polarity of microtubules?
A.
B.
C.
D.
30.  Which of the following is a function of Intermediatefilaments
A.
B.
C.
D.
E.
31.  The concentration of actin monomers is high in thecytosol. What keeps these monomers frompolymerizing totally into filaments?
A.
B.
C.
D.
E.
32.  Avery, MacLeod, and McCarty (1944) demonstratedthat DNA was the molecule of heredity by treating heatkilled Streptococcus pneumoniae S (smooth) strainwith DNase, thereby preventing transfer of the"transforming substance" from the killed S strain to thelive R (rough) strain when the two were mixed togetherand injected into mice. Another way that one coulddemonstrate transformation in bacteria would be toextract DNA from
A.
B.
C.
D.
33.  Cell crawling depends on
A.
B.
C.
D.
E.
34.  Which of the following is a DNA nucleotide?
A.
B.
C.
D.
E.
35.  How is the extent of DNA denaturation usuallymeasured?
A.
B.
C.
D.
E.
36.  Sequences of DNA that are similar, seeminglyconserved and seen in association with genes inroughly the same location from gene to gene inbacteria are called ________. They are generally themost common version of such a conserved DNAsequence, but some variation in the sequence canoccur from one gene to another
A.
B.
C.
D.
37.  What is sometimes needed for the termination ofbacterial transcription
A.
B.
C.
D.
38.  You are attempting to determine if a cell culture hasbeen infected by a particular virus. You isolate DNAfrom the sample and add PCR primers complementaryto viral DNA. What would you expect to happen ifthere has been no infection by the virus?
A.
B.
C.
D.
E.
39.  Bacteria are grown in a medium containing 15NH4Cl fora number of generations so that all of the DNA is madeof fully "heavy" DNA. The bacteria are moved to a newmedium and grown in 14NH4Cl so that all new DNA willbe "light". If replication were dispersive, what wouldthe DNA look like after one generation time.
A.
B.
C.
D.
E.
40.  Which of the following DNA molecules would not serveas an effective template for DNA synthesis?
A.
B.
C.
D.
E.
41.  Which of the following relieves mechanical strain thatbuilds up during replication in E. coli?
A.
B.
C.
D.
E.
42.  DNA polymerases always synthesize new DNA byadding nucleotides on to the 5Œ phosphate
A.
B.
43.  The DNA strand growing away from the replicationfork grows _______ in a 5'—>3' direction and is calledthe ________.
A.
B.
C.
D.
E.
44.  DNA and RNA polymerases have which of thefollowing properties in common?
A.
B.
C.
D.
E.
45.  The sigma subunit of bacterial RNA polymerase
A.
B.
C.
D.
E.
46.  Which of the following are components of Chargaff'srules of bases?
A.
B.
C.
D.
E.
47.  When a microtubule is growing, the plus end is presentas an open sheet to which GTP-dimers are added. Acap of GTP-dimers can often form on the growingmicrotubules during rapid growth periods. How doesthis cap form?
A.
B.
C.
D.
E.
48.  Enzymes that alter the supercoiled or topological stateof DNA by further supercoiling it or relaxing it arecalled _______. They are found in both prokaryoticand eukaryotic cells.
A.
B.
C.
D.
E.
49.  You are studying two samples of DNA that areidentical in length. The first has an A + T/G + C ratioof 4.5, while the second has a ratio of 2.3. Which ofthe following statements is true of the first sample?
A.
B.
C.
D.
E.
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