Flashcard Set Preview
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| 1 |
What drug relaxes smooth muscle but can cause tachycardia?
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isoproterenol (b2 relaxes bronchioles, b1 on heart)
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| 2 |
What drug is used during an acute asthma exacerbation to relax bronchial smooth muscle?
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albuterol
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| 3 |
What drug, used as prophylaxis, is associated with tremor and arrhythmia?
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Salmeterol
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| 4 |
What drug causes bronchodilation by inhibiting phosphodiesterase?
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methylxanthines (theophylline)
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| 5 |
What is increased by this inhibition?
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cAMP levels increase bc drug blocks its hydrolysis by phosphodiesterase
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| 6 |
What drug blocks muscarinic receptors in the bronchioles?
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muscarinic antagonists (ipratropium)
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| 7 |
What drug is used to treat COPD?
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Ipratroprium
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| 8 |
What drug is ONLY useful for prophylaxis of an asthma attack and CANNOT be used for an acute...
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cromolyn
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| 9 |
What drug blocks the release of mediators from mast cells?
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Cromolyn
Narrow TI causing cardiotoxicity, vomiting, diarrhea, seizures,...
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| 10 |
What drug blocks the conversion of arachidonic acid to leukotrienes?
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Zileuton (anti-leukotriene)
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| 11 |
What drugs blocks leukotriene receptors?
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zafirlukast, montelukast
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| 12 |
What drugs are good for aspirin induced asthma?
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Leukotriene receptor blockers- zafirlukast, montelukast
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| 13 |
What drugs inhibit synthesis of virtually all cytokine?
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corticosteroids (beclomethasone, prednisone)
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| 14 |
What drug inactivates NFkb?
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corticosteroids (beclomethasone, prednisone)
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| 15 |
What is NFkB?
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NfKB= transcription factor that induces production of TNFa, along with other inflamm agents
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| 16 |
What drug class is the first line therapy for chronic asthma?
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STEROIDS
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| 17 |
What drug removes excess sputum but doesn't necessarily suppress the cough reflex?
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Guaifenesin (Robitussin)
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| 18 |
What drug is mucolytic?
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N-acetylcysteine
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| 19 |
What drug is used to loosen mucus plugs in CF?
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N-acetylcysteine
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| 20 |
What drug is an endothelin receptor antagonist?
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Bostentin
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| 21 |
What is it used for?
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to decrease pulmonary vascular vascocontriction in idiopathic pulmonary fibrosis
...
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| 22 |
What are the second generation H1 blockers?
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Loratadine, fexofenadine, desloratadine, cetirizine
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| 23 |
Why do 2nd generation H1 blockers cause less sedation?
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less CNS penetration
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| 24 |
What are some side effects associated with 1st gen H1 blockers?
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sedation, weight gain, dry mouth, orthostatic hypotension, etc.
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| 25 |
What are the 1st gen H1 blockers?
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Dephenhydramine, dimenhydrinate, chlorpheniramine, hydroxizine, promethazine
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