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| Front | Back |
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What is the prototype drug for para-aminophenol derivatives?
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Acetaminophen
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What is the action of tylenol? What does it NOT do?
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Reduces pain
Does NOT suppress inflammation
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Acetaminophen can come as an ______________ agent or in ___________ with a variety of other drugs.
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Individual
combination
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What is the MAXIMUM dose for a 24 hour period?
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4 grams
NOTE: it is very easy to exceed this dose
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What is the usual dosing?
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325-650 mg q 4-6 hours max of 5 doses per day
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What is acetaminophen used to treat?
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Mild to moderate pain and fever
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What is the brand name for acetaminophen?
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Tylenol
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What happens in a tylenol overdose?
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Fulminant hepatic failure; jaundice; kidneys shut down and loss of consciousness; an urgent transplant may be required
MAY BE FATAL and requires treatment in acute care setting
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What is the onset and duration of acetaminophen?
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Onset: 10-30 minutes
duration: 3-5 hours
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What is the peak and half-life or acetaminophen?
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Peak: 60 minutes
half-life - 1-3.5 hours
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Acetaminophen is metabolized through the _______.
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Liver
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Normal doses go through the _______ pathway, and produce __________.
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Major
non-toxic metabolites
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If the liver is slow (like if you've been drinking) or the dose is to large, acetaminophen is metabolized down the _______________.
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Minor pathway
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When acetaminophen is metabolized down the minor pathway, it increases ________ ___________, causing ________ _________.
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Toxic metabolites
liver damage
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How does the minor pathway in the liver metabolize acetaminophen?
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Oxidized by P450-enzyme converts into toxic metabolites
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