Skin Histopathology

43 cards

8/12/10 8 AM


 
  
Created Aug 15, 2010
by
laurnb22

 

 
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1
What 4 things must be done before turning on the microscope?
 
Tissue processingH&E stainSpecial stainsImmunohistochemistry
2
What is tissue processing?
 
Skin biopsy, fix tissue in formalyn
3
What is H&E stain?
 
Standard stain for all tissues- stains the nuclei purple (hematoxylin) and the cytoplasm pink...
4
What is immunohistochemistry?
 
Selecting for certain proteins in tissue sample.  Use antibody to bind to a certain antigen...
5
What are the 4 primary cells of the epidermis?
 
KeratinocytesMelanocytesLangerhans cellsMerkel cells
6
What are the 3 primary components of the dermis?
 
FibroblastsDermal fibers (collagen, elastin)Ground substance 
7
What are the adnexae?
 
Hair folliclesSebaceous glandsSweat glands
8
Skin pathology is divided into what 2 types of disorders?
 
1. Non-neoplastic (inflammatory, infectious, immunologic)2. Neoplastic
9
How is a skin disorder diagnosed?
 
By pattern recognition
10
What are the microscopic patterns in the epidermis?
 
1. Hyperkeratosis (orthohyperkeratosis, parahyperkeratosis)2. Hyper/hypogranulosis3. Acanthosis...
11
What is parakeratosis?
 
Hyperplasia + visible nuclei in the stratum corneum
12
What is an example of a skin disorder with orthohyperkeratosis?
 
Lichen planus
13
What is an example of a skin disorder with parakeratosis?
 
Psoriasis
14
What is hypergranulosis?
 
Hyperplasia of the stratum granulosum
15
What is hypogranulosis?
 
Hypoplasia of the stratum granulosum
16
As a rule of thumb, which of these goes together?
 
Orthohyperkeratosis - hypergranulosisParakeratosis - hypogranulosis
17
What are the 4 microscopic patterns in the dermis?
 
1. Dermal infiltrates (superficial perivascular, superficial and deep, lichenoid, diffuse infiltrates)2....
18
What is the microscopic pattern in the subcutis?
 
Inflammation of subcutis = panniculitisseptal infalmmationlobular inflammation
19
What are the 2 types of alterations in skin pigmentation?
 
1. Hyperpigmentation2. Hypopigmentation
20
Hyperpigmentation
 
Histiocytes accumulate in superficial dermiscommon after dermatitis
21
Hypopigmentation
 
Lack of melanocytes and pigmentationcommon in vitiligo
22
Name the 3 spongiotic dermatoses
 
1. Contact dermatitis2. Nummular dermatitis3. Autosensitization reaction
23
Name the 2 vacuolar interface dermatoses
 
1. Lichenoid infiltrate (lichen planus)2. Without lichenoid infiltrate (lupus, erythema multiforme,...
24
Name the 3 psoriasiform dermatoses
 
PsoriasisPityriasis rubraLichen simplex chronicus
25
Intraepidermal blisters are called ________
 
Pemphigus
26
Subepidermal blisters are called ____
 
Pemphigoid
27
What is a neoplasm?
 
Abnormal growth of a tissue that continues even after the stimulus is gone.
28
What is seborrheic keratosis?
 
Benign neoplasm of the keratinocytes
29
What are the intermediate neoplasms of keratinocytes?
 
Actinic keratosisSquamous cell carcinoma in situ
30
What are the malignant neoplasms of keratinocytes?
 
Invasive SCCBCC
31
What is seborrheic keratosis?
 
Benign growthClinically - tan to dark brown, smooth, round lesion; stuck-on appearanceHistologically...
32
What is actinic keratosis?
 
Preneoplastic lesion caused by sun exposureatypical keratinocytes in the lower part of the...
33
What is solar elastosis?
 
Bluish changes seen in epidermis due to sun damage
34
What is squamous cell carcinoma?
 
The 2nd most common tumor (BCC > SCC > melanoma)Caused by  = sun exposure, carcinogens,...
35
What is the histologic appearance of SCC in situ?
 
Atypical keratinocytes that span the full thickness of the epidermis, but do not go into the...
36
What is the histologic appearance of SCC invasive?
 
Nests of atypical keratinocytes invading the dermiseosinophilic cytoplasm and large, vesicular...
37
what is basal cell carcinoma?
 
Most common skin cancerMalignant, slow-growing tumor that does NOT metastasize
38
What is the clinical appearance of BCC?
 
Pearly, telangiectatic noduleRodent ulcer
39
What is the histologic appearance of BCC?
 
Basaloid (bluish) cells in nodules, does not invade the dermis, surrounding by peripheral palisading 
40
What is a dermatofibroma?
 
Benign tumor of the fibroblast (main cell of the dermis)
41
What is the clinical apperance of a dermatofibroma?
 
Tan to brown firm papules
42
What is the histologic appearance of a dermatofibroma?
 
Fibroblasts, foamy histiocytes, and overlying epidermal hyperplasia
43
What is a dermatofibrosarcoma protuberans?
 
A well-differentiated fibrosarcoma of the skin that rarely metastasizes but is locally aggressiveFirm...

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