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Related Flashcards
Cards In This Set
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Gastric - incidence (U.S.) and annual deaths
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22,000 and 12,000
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Gastric - age, sex, and race
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Peaks in 60s, rare before age 40. More common in men (2:1) and in afr. am., native amer, and hispanics. Very common in Asia.
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Gastric - risk factors
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Envir factors, higher in lower socioeconomic status, increased risk if smoked, salted, poorly preserved foods, lower risk with high fruits/veg, h. Pylori
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Gastric - genetics
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E-cadherin gene (CDH-1) mutation - hereditary diffuse gastric adenocarc - 70% lifetime risk; loss of p53; mismatch repair gene mutations (HNPCC, etc); BRCA2; activation of proto-onc c-met and K-sam
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Gastric - Borrmann's classification: I
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Papillary, mainly exophytic
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Gastric - Borrmann's classification: II
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Ulcerative
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Gastric - Borrmann's classification: III
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Ulcerative and infiltrating (without distinct borders)
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Gastric - Borrmann's classification: IV
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Infiltrative diffusely (linitus plastica)
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Gastric - histologies
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90-95% adenocarc., also can have lymphoma (MALToma), GIST (surgery +/- Gleevac), leiomyosarcoma, carcinoid, SCC
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Branches of abdominal aorta (superior to inferior)
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Celiac, SMA, (renals, testicular/ovarian, lumber), IMA
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Branches of celiac artery
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Left gastric artery, splenic, hepatic
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Gastric - 2002 AJCC
T1
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Invasion of lamina propria or submucosa
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Gastric - 2002 AJCC
T2
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Invasion of beyond submucosa, can be through muscularis propria or sub-serosa
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Gastric - 2002 AJCC
T3
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Invasion of serosa (visceral peritoneum) without involvement of adjacent structures
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Gastric - 2002 AJCC
T4
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Invasion of adjacent structures
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