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Side ASide B
The first committed step of Pyrimidine Synthesis?
CPSII Carbamoyl Phophate Synthase II
Symptoms:Hyperammonemia Build up of Orotic Acid in blood and UrineLethargic , loss of apetite - (Neonate)Seizures , Coma, Brittle Hair
OTC DeficiencyOrnithine transcarbomylase Deficiency
SymptomsNo hyperammonemiaNo BUNExcessive orotic acid in urineMegaloblastic AnemiaNo DNA+RNA synth: Mental+Physical retardation
Anticancer : antineoplasic.Can be inhibited by Hydroxyurea
Anticancer : antineoplasic.Can be inhibited by 5-Fluoro-Uridine
Can be blocked by MethotrexateTrimethoprimPrimethamine
What catalyzes first step in Purine biosynthesis?
Catalyzes the formation of uric acid?
Uric Acid buildup ? how do you treat?
GOUTTreat by prescribing Xanthine Oxidase inhibitor: ALLOPURINOL
ALLOPURINOL is what type of inhibitor?
NON-Competitive inhibitor. Elimminated enzymes, raises Km. Increasing subrstrate level.
defect in Purine De Novo synth pathway?SymptomsSelf mutilation (biting fingertips)
LESCH NYAN SYNDROME
What enzyme salvages Adenine to make IMP+Guanine to make GMP?
Hypoxanthine Guanine Phophoribosyl Transferase