Pyrimidine + Purine Synthesis

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Questions Regarding Pyrimidine And Purine Synthesis

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The first committed step of Pyrimidine Synthesis?
 
CPSII Carbamoyl Phophate Synthase II
Pyrimidine precursor?
 
(Orotate)Orotic Acid
Symptoms:
Hyperammonemia Build up of Orotic Acid in blood and UrineLethargic , loss of apetite - (Neonate)Seizures , Coma, Brittle Hair
 
OTC DeficiencyOrnithine transcarbomylase Deficiency
Symptoms
No hyperammonemiaNo BUNExcessive orotic acid in urineMegaloblastic Anemia
No DNA+RNA synth: Mental+Physical retardation
 
Orotic Aciduria
Anticancer : antineoplasic.Can be inhibited by Hydroxyurea
 
Ribonucleotide Reductase
Anticancer : antineoplasic.Can be inhibited by 5-Fluoro-Uridine
 
Thymidilate Synthase
Can be blocked by MethotrexateTrimethoprimPrimethamine
 
Dihydrofolate Reductase
What catalyzes first step in Purine biosynthesis?
 
PRPP AMIDOTRANSFERASE
Catalyzes the formation of uric acid?
 
XANTHINE OXIDASE
Uric Acid buildup ?
how do you treat?
 
GOUT
Treat by prescribing Xanthine Oxidase inhibitor: ALLOPURINOL
ALLOPURINOL is what type of inhibitor?
 
NON-Competitive inhibitor. Elimminated enzymes, raises Km. Increasing subrstrate level.
defect in Purine De Novo synth pathway?
Symptoms
Self mutilation (biting fingertips)
 
LESCH NYAN SYNDROME
What enzyme salvages Adenine to make IMP+Guanine to make GMP?
 
Hypoxanthine Guanine Phophoribosyl Transferase
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