Pyrimidine + Purine Synthesis

Questions Regarding Pyrimidine And Purine Synthesis
 
Created Apr 17, 2012
by
a200holdup
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Side ASide B
The first committed step of Pyrimidine Synthesis?
CPSII Carbamoyl Phophate Synthase II
Pyrimidine precursor?
(Orotate)Orotic Acid
Symptoms:Hyperammonemia Build up of Orotic Acid in blood and UrineLethargic , loss of...
OTC DeficiencyOrnithine transcarbomylase Deficiency
SymptomsNo hyperammonemiaNo BUNExcessive orotic acid in urineMegaloblastic AnemiaNo DNA+RNA...
Orotic Aciduria
Anticancer : antineoplasic.Can be inhibited by Hydroxyurea
Ribonucleotide Reductase
Anticancer : antineoplasic.Can be inhibited by 5-Fluoro-Uridine
Thymidilate Synthase
Can be blocked by MethotrexateTrimethoprimPrimethamine
Dihydrofolate Reductase
What catalyzes first step in Purine biosynthesis?
PRPP AMIDOTRANSFERASE
Catalyzes the formation of uric acid?
XANTHINE OXIDASE
Uric Acid buildup ? how do you treat? 
GOUTTreat by prescribing Xanthine Oxidase inhibitor: ALLOPURINOL
ALLOPURINOL is what type of inhibitor?
NON-Competitive inhibitor. Elimminated enzymes, raises Km. Increasing subrstrate...
defect in Purine De Novo synth pathway?SymptomsSelf mutilation (biting fingertips)
LESCH NYAN SYNDROME
What enzyme salvages Adenine to make IMP+Guanine to make GMP?
Hypoxanthine Guanine Phophoribosyl Transferase


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