Pyrimidine + Purine Synthesis

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Questions Regarding Pyrimidine and Purine Synthesis


 
  
Created Apr 17, 2012
by
a200holdup

 

 
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1
The first committed step of Pyrimidine Synthesis?
 
CPSII Carbamoyl Phophate Synthase II
2
Pyrimidine precursor?
 
(Orotate)Orotic Acid
3
Symptoms:
Hyperammonemia Build up of Orotic Acid in blood and UrineLethargic , loss...
 
OTC DeficiencyOrnithine transcarbomylase Deficiency
4
Symptoms
No hyperammonemiaNo BUNExcessive orotic acid in urineMegaloblastic Anemia
No...
 
Orotic Aciduria
5
Anticancer : antineoplasic.Can be inhibited by Hydroxyurea
 
Ribonucleotide Reductase
6
Anticancer : antineoplasic.Can be inhibited by 5-Fluoro-Uridine
 
Thymidilate Synthase
7
Can be blocked by MethotrexateTrimethoprimPrimethamine
 
Dihydrofolate Reductase
8
What catalyzes first step in Purine biosynthesis?
 
PRPP AMIDOTRANSFERASE
9
Catalyzes the formation of uric acid?
 
XANTHINE OXIDASE
10
Uric Acid buildup ? 
how do you treat? 
 
GOUT
Treat by prescribing Xanthine Oxidase inhibitor: ALLOPURINOL
11
ALLOPURINOL is what type of inhibitor?
 
NON-Competitive inhibitor. Elimminated enzymes, raises Km. Increasing subrstrate...
12
defect in Purine De Novo synth pathway?
Symptoms
Self mutilation (biting fingertips)
 
LESCH NYAN SYNDROME
13
What enzyme salvages Adenine to make IMP+Guanine to make GMP?
 
Hypoxanthine Guanine Phophoribosyl Transferase

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