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| 1 |
ASA
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anti-plateletirreversible COX inhibition--> no PGI2 (on endothelium, anti-aggregatory) or...
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Clopidogrel
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Plavix, anti-plateletADP receptor antagonistadditive to ASA, metabolized in liverSE--neutropenia
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Abciximab
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anti-plateletGpIIa/IIIb receptor antagonist-->blocks fibrinogen bindingmonoclonal Ab i.v.
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Epoprostenol
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anti-plateletsynthetic PGI2i.v.
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Cilostazol
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anti-plateletPDEIII inhibitorused for PAD, decreased claudication
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Heparin
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anticoagbinds and enhances anti-thrombin, inactivates IIa, Xai.v., fast onset, aPTT monitoring
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Enoxaprin
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anticoagLMWH, only affects Xai.v./s.c.more predictable pharmacokinetics, consistent quality,...
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Fondaparinux
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anticoagselective inhibitor of Xa
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Warfarin
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anticoagoral Vit K antagonist-->impaired synthesis of II, VII, IX, Xnarrow therapeutic window,...
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Alteplase
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fibrinolytici.v. to lyse clot, recombinant tissue plasminogen activator (tPA)SE--hemorrhage
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Streptokinase
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fibrinolytici.v. to lyse clot, bacterial productSE--may cause allergic rxn, hemorrhage
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Urokinase
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fibrinolytici.v. to lyse clot, human kidney cell culturesSE--hemorrhage
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Tranexzamic acid
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hemostaticplasminogen inhibitor
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Protamine sulphate
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hemostaticheparin inhibitor
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PT
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extrinsic pathwayTF, VII, II, IX, Xwarfarin dosing
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PTT
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intrinsic pathwayTENET: XII, XI, IX, VIII, X
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