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Where can you find carbonic anhydrase inhibitors?What is their MOA?
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Mostly proximal tubule, a little in the distal tubuleMOA: inhibits carbonic anhydrase which...
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| 2 |
What is the net effect of a carbonic anhydrase inhibitor?
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Urine = more alkaline, because H+ is no longer getting put into urine and bicarb is staying...
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What are carbonic anhydrase inhibitors clinically used for?
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Limited use with diuretics - for liver cirrhosis, nephrotic syndrome, and renal failureCysteinuria...
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What are three side effects to CAIs?
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Metabolic acidosisDrowsinessHypersensitivity to thiazide diuretics
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Where can you find osmotic diuretics?What is their MOA?
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Throughout the nephron especially works in the loop of Henle - more H2O reaches thick ascending...
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Are osmotic diuretics metabolized?Are they reabsorbed?Do osmotic diuretics get completely filtered?Are...
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No.No or very little.Yes.Yes.
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How should osmotic diuretics be given?
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via IV in large doses
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What are osmotic diuretics used for?
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Acute renal failure prevention - gets the toxins outWhenever there's low GFR (like from trauma,...
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What are the two side effects of osmotic diuretics?
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volume overloadmay precipitate cardiac failure
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| 10 |
What do osmotic diuretics do in the loop of Henle?
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Descending and ascending loops do not absorb water or NaClTransport processes in the thick...
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| 11 |
Which diuretic has the maximum loss of sodium?
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Loop diuretics
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| 12 |
Where do loop diuretics work in the nephron?What is their MOA?
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Thick ascending limbInhibit the Na-K-2Cl symporterThe macula densa can't sense NaCl -> Prostaglandins...
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The loop diuretics create an increased excretion of what six electrolytes?
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Na, Cl, K, H, Ca, Mg
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