Flashcard Set Preview
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| 1 |
Classic stimulator of P450 enzymes
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Phenobarbital
(also increases metabolism of other drugs, including phenobarbital)
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| 2 |
How can the liver be damaged and have less P450 and other enzymes?
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toxic agents like CCl4
(irreversible)
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| 3 |
Half life in the elderly (vs. young)
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much longer (less liver function)
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| 4 |
Enteral drug absorption--rate
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1st order (dependent on conc)
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| 5 |
Elixir
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drug suspended in (water + EtOH)
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| 6 |
Preparations containing finely divided drug particles distributed throughout; drug is insoluble
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Suspension
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| 7 |
Some drugs are injected after being linked to an oily C chain. This now weakly water-soluble...
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Depot drug -- IM injection
0 order -- depends on levels of enzyme
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| 8 |
This act in Congress said that drugs must be safe, but not necessarily effective.
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The Federal Food, Drug, and Cosmetic Act of 1938
also, meds can be used...
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| 9 |
Saturated enzyme is an example of what rate?
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0 order
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| 10 |
Passive diffusion is an example of what rate?
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1st order
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| 11 |
Rate of glomerular filtration
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1st order
(depends on conc)
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| 12 |
Rate of tubular secretion
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0 order -- saturatable enzyme
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| 13 |
Rate of tubular reabsorption
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1st order (passive diffusion)
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| 14 |
To call a drug eliminated, how many half-lives would it have to go through?
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4
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| 15 |
Why is it not really useful to give a big dose to a patient and let them maybe take 1 tablet...
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1. toxicity
2. excretion is 1st order -- body will just excrete more rapidly
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