Flashcard Set Preview
| Side A | Side B | ||
| 1 |
Animal prion disease
|
BSE in cows (bovine spongiform enceph)
|
|
| 2 |
Prions are...
|
transmissable damaged PrP protein coded by PRNP on chromosome 20. resistant to proteases.
|
|
| 3 |
How is PrP damaged in prions?
|
alpha-PrPc to beta-PRPsc
|
|
| 4 |
Two causes of iatrogenic (from a medical tx) infections of CJ Disease
|
corneal transplants
hGH
|
|
| 5 |
Clinical findings in CJ Disease
|
Rapidly progressing dementia
Startle myoclonus (involuntary jerking when surprised)
|
|
| 6 |
Prognosis for CJ patient
|
0--it is always fatal. Avg of 7 months
|
|
| 7 |
How does variant CJ D present differently?
|
younger people
neuro sx progress slower, but behavior issues noticeable earlier
no alterations...
|
|
| 8 |
What is vCJ D linked to?
|
BSE
|
|
| 9 |
**Microscopic findings for vCJ?
|
cortical plaques surrounded by a halo of spongiform change
|
|
| 10 |
In fatal familial insomnia, what does it have?
1. Spongiform change
2. Neuronal loss
3....
|
No
Yes
Yes
Yes
|
|
| 11 |
This inherited prion disease begins with cerebellar ataxia then progressive dementia. Death...
|
Gerstmann-Straussler-Scheinker S
|
|
| 12 |
Microscopic findings of GSSS?
|
Kuru plaques--aggregates of PrPsc
|
|
| 13 |
Most common demyelinating disorder
|
MS
|
|
| 14 |
Immune mechanism that damges myelin in MS
|
CD4+ TH1 cells vs. myelin --> ING-g --> MACs
|
|
| 15 |
Where do you see the gross glassy, gry plaques in MS?
|
White matter; around the lateral ventricles
|
No comments yet! Be the first to add a comment below!
Please login to post comments.
After login, we will forward you back to this flashcard.