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This is the area of the LN where B cells interact with antigen
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Germinal center
GERMinal center
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This area of the LN is involved in cellular immunity.
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Paracortical T cell zone
Tc cells
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| 3 |
This is where naive B cells live.
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Mantle zone
Around the germinal center
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| 4 |
Leukopenia is
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decreased WBCs -- usually NTs
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Lymphopenia is
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decreased B and T cells
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| 6 |
Normal WBC count
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3.5 - 10 x 10^3 / uL
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Most --> least common WBCs
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NTs
Lymphocytes
Monocytes
Eosinophils
Basophils
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| 8 |
Agranulocytosis
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severe reduction in NTs
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| 9 |
Most common cause of neutropenia
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drugs
alkylating agents and antimetabolites
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| 10 |
BM of neutropenia
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Hypercellular: excessive destruction
Hypocellular: supress granulocytic precursors
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| 11 |
Complication of neutropenia?
When?
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Infections; esp bacteria & fungi
<500 /mm3
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| 12 |
Increase in the # of WBCs
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leukocytosis
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| 13 |
2 things that cause increased release of WBCs from marrow
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acute infection / endotoxemia
hypoxia
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Decreased margination of WBCs b/c of
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epinephrine / exercise
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Decreased extravasation into tissue
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glucocorticoids
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| 16 |
Increased # of marrow precursors
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chronic infection
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| 17 |
Neutrophilia caused by
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acute bacterial infections
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| 18 |
Monocytosis is caused by
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chronic infections, endocarditis, rickettsia, malaria, IBD
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| 19 |
Lymphocytosis is caused by
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viral infection
chronic infection
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| 20 |
Neutrophilia is caused by what cytokine?
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IL-1, TNF
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| 21 |
Eosinophilia is caused by
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IL-5
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| 22 |
Lymphocytosis is caused by
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IL-7
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| 23 |
What are the 3 changes in toxic neutrophils?
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toxic granulation
Dohle bodies
Cytoplasmic vacuoles
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| 24 |
Atypical lymphocytes seen in
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EBV
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| 25 |
Leukomoid reaction
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numerous immature granulocytes appear in blood
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| 26 |
Pt presents with red, swollen tender LNs. Mic: prominent lymphoid follicles with alrge germinal...
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Acute nonspecific lymphadenitis
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| 27 |
What is different about LNs in chronic nonspecific lymphadenitis?
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LNs are not tender
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| 28 |
3 changes in chronic nonspecific lymphadenitis
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follicular hyperplasia
paracortical lymphoid hyperplasia
sinus histiocytosis
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| 29 |
In follicular hyperplasia, what proliferates?
Cells in germinal center? (2)
MACs?
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B cells
Centroblasts
Centrocytes
Tingible-body MACs
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| 30 |
Paracortical lymphoid hyperplasia is often caused by
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EBV -- acute viral infection of infectious mono
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| 31 |
What paracortical cellular change in paracortical lymphoid hyperplasia?
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Immunoblasts: activated T cells
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| 32 |
Most lymphoid neoplasms are ____ origin.
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B cell (>80%)
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