Flashcard Set Preview
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1. location of smooth muscle in the conducting airways2. smooth muscle cells3. shape of smooth...
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1. trachea to terminal bronchioles2. myocytes3. elongated, spindle-shaped and blunt at both...
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1. what does smooth muscle have that are similar to Z-lines in skeletal muscle?2. location...
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1. dense bodies and dense plaques2. dense bodies= thru-out sarcoplasmdense plaques= just under...
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1. Dense bodies are scattered ____ in the ____2. dense bodies are interconnected by what?3....
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1. longitudinally/ cytoplasm2. intermediate protein filaments as well as thick and thin myofilaments3....
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1. what allows actin (thin) filaments to slide past myosin (thick) filaments?2. result of #13....
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1. phosphorylation of thick myosin filaments by ATP activates myosin2. shortening or contraction...
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four types of stimulation in airway smooth muscle
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neuralhumorallocal chemical (paracrine)physical
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1. Neural a. airway smooth muscle contracts by responding to what? b....
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1a. postganglionic, parasympathetic innervationb. majorc. NANC system
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1. Humoral stimulation by what? - source of these hormones?2. Local chemical (_____)...
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1. hormones in the bld- NE and Epi- adrenal glands2. paracrine/ respiratory epithelium- histamine,...
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Parasympathetic Neural Stimulation1. achieved by what?2. axon terminals contain what?3. ___...
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1. unitary stimulation via the vagus nerve2. ACh vesicles3. action potential4. Ach is rls'd...
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1. ACh can combine with which two receptors? and their locations?2. what do each of the receptors...
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1. M3 receptors on the plasma membrane of myocytes or with M2 receptors on the surface membrane...
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Specific Mechanism for Normal Resting Bronchoconstriction Tone1. ___ rls'd from nerve endings,...
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1. ACh- stimulates depolarization in the plasma membrane - binds to a GPCR2. causes Ca...
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5. what dissociates and migrates along the ___ ___ to _____, an ____6. ___ activates ___ which...
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5. alpha subunit of the G-protein (Gqa) dissociates and migrates along the plasma membrane...
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IP3 Pathway8. IP3 ___ and binds to its receptors in the ___ ___9. result of #8
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8. translocates/ sarcoplasmic reticulum membrane9. IP3 opens channels in the SR and Ca is released...
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Ryanodine Channel Pathway10. RyR channels in the SR react to what?11. reaction causes what?12....
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10. ryanodine (a plant alkaloid)11. causes Ca to be released from SR into cytoplasm12. ACh...
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Smooth Muscle Cell Contraction1. controlled by what?2. Increased (Ca)I causes what?3. complex...
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1. (Ca)I2. Ca to bind to Calmodulin (a cytoplasmic protein) forming a Ca-Calmodulin complex3....
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5. phosphorylation of myosin head6. result of #5?
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5. another ATP molecule must be broken down to initiate and energize cross-bridge cycling in...
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