Flashcard Set Preview
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| 1 |
parts of periodontium
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-cementum-PDL-bony socket-junctional epithelium-sulcular epithelium (not involved in attachment)
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| 2 |
inductive signal for root dentinogenesis is from?
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HERS
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| 3 |
cementoblast origin
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dental follicle
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| 4 |
why does the outermost layer of dentin remain unmineralized during cementogenesis?
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allows collagen fibers of dentin and cementum to mingle prior to mineralization --> provides...
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| 5 |
fiber fringe attaches _____ to _____
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cementum to dentin
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| 6 |
which type of cementum forms more rapidly?
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Cellular
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| 7 |
cementoblasts derive from?
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dental follicle (neural crest ectomesenchyme) and HERS (ectodermal epithelium)
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| 8 |
molecule implicated in cementoblast induction?
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BMPs (growth factors)
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| 9 |
molecule implicated in cementoblast differentiation?
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Runx (transcription factor)
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| 10 |
ECM matrix molecules implicated in cementogenesis?
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bone sialoprotein --> promote mineral formationosteopontin --> inhibit mineral formation
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| 11 |
collagen in organic component of cementum
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Type I (90%) and Type III (10%)
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| 12 |
which cementum type is more mineralized?
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primary
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| 13 |
cells of PDL?
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-fibroblasts (most numerous)-cementoblasts-osteoblasts-osteoclasts-epithelial rests of Malassez-immune...
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| 14 |
fibroblast junctions
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desmosomes (cell-cell) and fibronexus (cell-EMC) maintain organized nature of PDL bundle fibers...
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| 15 |
fibronexus features
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link cell (fibroblast) to ECMcytoskeleton (actin) linked to intracellular attachment plaque,...
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| 16 |
fibronexus can be found in?
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PDL
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| 17 |
PDL v gingiva fibroblastsCollagen turnover?Cell volume?Proliferation rates?Collage/fibronectin?
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FasterHigherHigherHigher (collagen almost always associated with fibronectin)
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| 18 |
collagen in ECM of PDL
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collagen type I (80%) and type III (20%)
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| 19 |
what is oxytalin?
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immature elastic fibers found in ECM of PDL
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| 20 |
important function of GAGs in ground substance of PDL ECM?
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water retention -- helps withstand compressive loads
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| 21 |
what is tenacin?
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glycoprotein concentrated around Sharpey's fibers of PDL
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| 22 |
origin of bundle bone?
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dental follicle
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| 23 |
what are beta-defensins?
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antimicrobial peptides secreted by epithelial cells
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| 24 |
oral epithelia with slowest turnover? fastest?
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slowest -- gingivafastest -- junctional epithelium (5-10 days)
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| 25 |
cytokeratins assemble into what type of cytoskeleton?
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intermediate filaments
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| 26 |
epidermolysis bullosa simplex is caused by mutation to?
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cytokeratins 5/14
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| 27 |
white sponge nervus caused by mutation to?
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cytokeratins 4/13
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| 28 |
what complexes form in keratinized epithelium, and what is their function?
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cytokeratin (tonofibril) - fillagrin complexeshelp to crowd out other organelles and promote...
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| 29 |
reasons for permeability difference between keratinized and nonkeratinized epithelium
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-desmosomes -- more numerous-membrane coating granules -- create effective barrier-membrane...
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| 30 |
what is loricrin
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protein composing cornified envelope in keratinized epithelium
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| 31 |
what is elastin?
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elastic fibers in lamina propria ECM
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| 32 |
which regions of oral cavity contain no submucosa?
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-gingiva-hard palate next to gingiva-rugae region-midian raphe-also, tongue
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| 33 |
what is tas2r
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bitter receptor
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| 34 |
type of cytokeratin found in all 3 types of taste bud?
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K19
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| 35 |
which collagen type is main component of bone organic matrix?
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type I
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| 36 |
functional unit of compact bone?
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secondary osteon
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| 37 |
how is osteoclastogenesis regulated?
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RANK receptor on preosteoclastRANKL on preosteoblast stimulates osteoclastsOPG inhibits RANK...
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| 38 |
most abundant cell type of bone?
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osteocyte
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| 39 |
transcription factors involved in osteoblast differentiation?
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Runx2 and Osx
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| 40 |
which cells sense loading in bone?
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osteocytes
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| 41 |
Sharpey's fibers insert into which layer of bone?
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bundle bone
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| 42 |
alveolar bone developed from tooth germs or jaw bone?
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tooth mesenchyme may also contribute to alveolar bone formation
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| 43 |
which cell plays the largest role in tooth movement?
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fibroblast
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| 44 |
what type of nerve fibers are polymodal nociceptors?
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C fibers
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| 45 |
which receptors are slow adapting (static forces)?
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Merkel receptors
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| 46 |
which receptors are rapidly adapting (dynamic forces)?
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Meissner's corpuscles
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| 47 |
what has taste buds that are responsive to water?
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larynx
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