NMB - Lecture 1-2

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NMB - Lecture 1-2

Created Apr 17, 2012
by abbyas2003

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	Side A	Side B
1	1. parts of peripheral nervous system and where NMB's work. a. conveys info from receptors...	1a. afferent systemb. efferent systemc. somatic nervous system--> where NMB's workd. autonomic...
2	1. Ach is stored in ___ at __ __ __2. nerve impulse ends with what?3. what part of Ach attaches...	1. vesicles/ motor end plate2. quanta of Ach is released into cleft from vesicles3. positively...
3	Nicotinic Ach Receptor1. each Ach receptor is a __ __ containing __ subunits= what are they?2....	1. pentameric protein/ 5 subunits-- 2 alpha, 1 beta, 1 delta, 1 gamma (fetal or epsilon = adult)2....
4	1. each subunit consists of what?-- spans what?2. the __ domain lines the ion channel which...	1. 4 helical domains labeled M1-M4 (AA strands)-- lipid bilayer2. M2 --> Na, K, Ca
5	1. AchE (acetylcholinesterase) = __ moleculea. how many AA long?b. daltons?2. Neuromuscular...	1. largea. 535 AAb. over 60,000 amu2. competitive-- greater concentration ("numbers game")
6	Neuromuscular Blockage Reversal1. what must be done to compete against NDMB?2. what is one...	1. increase Ach molecules2. block Ach breakdown with cholinesterase inhibitors (non-specific)3....
7	1. which 3 parts of nervous system does Ach affect?2. 4 limitations to the drug triad -->...	1. SNS = sweat glandsPNS = smooth muscle, heart, glandsskeletal/ motor2. side effectsindirect...
8	1. who is given credit for discovering curare in the amazon?2. curare toxicansa. ___ extractb....	1. Humbolt and Bernard2a. alkaloidb. chondrodendron tomentosumc. medicinal, currency, status,...
9	Civilized WOrld Uses of Curare1. structure identified when?2 . first used successfully for...	1. 19352. harold griffith and Johnson - Canadian Anesthesiologists3. Bohm and Lawen at Leipzig...
10	All Muscle Relaxants1. highly __-- low ___; high ___2. Vol of Dist?3. BBB, maternal barrier,...	1. ionized-- low lipophilicity, high hydrophilicity2. low Vol of Dist (in ECF primarily)3....
11	Non-Depolarizers action1. how is their action stopped?2. greatest affinity for which receptor?3....	1. at concentration in blood drops, NMB diffuses away from NMJ site to site of metabolism or...
12	Non-Depolarizer Metabolism1. 4 ways2. 2 ways in which they are excreted3. three general things...	1. liver, kidney, plasma and spontaneously2. in active and inactive forms3. organ insufficiencyenzyme...
13	Action at the Receptor1. depolarizers are __ at the __ receptors2. depolarizers prevent ___3....	1. agonists/ nicotinic2. repolarization3. succ's and decamethonium
14	Succinylcholine1. made of what?2. metabolized by what? not by ___3. length of time Sux lasts...	1. 2 Ach molecules bound together2. plasma cholinesterase enzyme not by acetylcholinesterase...
15	1. duration of NDNMB's depends on what?2. curare and its derivatives have an __ __ structure3....	1. dependent on equilibrium btw plasma concentration and extracellular concentration. as plasma...
16	1. Isoquinolines= sometimes called what? why?2. aminosteroidals = ___ backbone with 2...	1. benzylisoquinolines --> to account for benzene functional group that is attached to the...
17	SARs1. the __ charged __ __ group is __ attracted to the __ charged ___ receptor2. what binds...	1. the positively charged quaternary ammonium group is electrostatic ally attracted to the...
18	SARs1. ___ = bulky, rigid molecules cause non-depolarizing block2. ___= slender molecules cause...	1. pachycurares2. leptocurares3. interonium (btw N's) distance of 10 atoms or 20angstrom--...
19	CARs1. ___ changes account for __ __2. molecules prefer __ __ states and seek the shape that...	1. conformational/ receptor blockade2. low energy/ balance of energies3a. 4.4Ab. 5.9A
20	Neuromuscular Blockade Evolution(drug)1. 19422. 19523. 19584. 1964/685. 19656. 19717. 1982*8....	1. curare2. Sux3. nerve stimulators introduced - twitch mode4. alcuronium/ pancuronium5. nerve...