Flashcard Set Preview
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| 1 |
Muscle cell membrane
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endomysium
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| 2 |
What's inside muscle cells?
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Myofibrils
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| 3 |
What membrane lines myofibrils?
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sarcolemma?
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| 4 |
What are muscle fibres grouped into? What is this structure lined by?
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Fasciculi, perimysium
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| 5 |
What is the muscle belly lined by?
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epimysium
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| 6 |
What are the contractile units within the myofibril called?
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Sarcomeres
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| 7 |
What are sarcomeres composed of?
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Thick (myosin) and thin (actin) filaments
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| 8 |
What is the H band/zone?
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central area of sarcomere containing myosin, not overlapped by actin
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| 9 |
What is the A band?
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The sarcomere region containing myosin
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| 10 |
What is the I band?
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Sarcomere area containing actin only
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| 11 |
What is the Z line?
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Line in sarcomere where actin filaments are joined together
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| 12 |
What is the M line?
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A line in the sarcomere where myosin filaments are held in spatial arrangement
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| 13 |
What are the components of the thin filament?
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Actin, tropomyosin, Troponin (containing I, T and C subunits)
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| 14 |
What are the detailed components of the thick filaments?
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Myosin (head and tail). Myosin head has ATP binding site, actin binding site and myosin light...
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| 15 |
Which bands of the sarcomere change during muscle contraction?
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H and I bands diminish in width (A band stays the same)
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| 16 |
What is the term used to describe the actin myosin reaction
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actin-myosin POWER STROKE!
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| 17 |
Where is the principal area of calcium release during muscle cell contraction
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principally the terminal cisterns of the sarcoplasmic reticulum (NB lies close to the T tubules),...
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| 18 |
Where does the calcium bind, and what happens next?
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Calcium binds troponin C, causing a conformational change in troponin I and T, exposing active...
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| 19 |
Describe the myosin-actin contraction cyclee
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1) end of previous power stroke, actin is still bound to myosin. ATP binds myosin, causing...
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| 20 |
What's the name of the protein that binds calcium in the sarcoplasmic reticulum
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Calsequestrin
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| 21 |
What's another name for the calcium release channel in the sarcoplasmic reticulum?
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Ryanodine receptor
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| 22 |
What's the name of the calcium receptor on the T tubule system?
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Dihydropyridine receptor (slow Ca channel)
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