Flashcard Set Preview
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| 1 |
What type of properties does the cytoskeleton possess?
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-Dynamic properties: filaments (MT & actin) can grow and shrink rapidly
-Largest of cytoskeletal...
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| 2 |
-What distinguishes microtubules from other filaments?
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-Most rigid of filaments
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| 3 |
What are the functions of microtubules?
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-Organise ER and Golgi apparatus ("railroad" connecting...) where the trans golgi network is...
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| 4 |
- How are the alpha and beta-tubulin dimers arranged?
-Which subunit is the "-" end and which...
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-The alpha ("-" end) contacts the beta subunit ("+" end) of the next dimer.
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| 5 |
-In the alpha/beta tubulin dimer, what happens if GTP is bound to the beta-tubulin?
-What...
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-If GTP is bound to the beta-tubulin, the alpha/beta dimer has high affinity for other substrates
-If...
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| 6 |
Explain nucleation in microtubules.
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-Beta tubulin GTP is gradually hydrolysed to GDP + Pi
- If the GDP-tubulin reaches the growing...
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| 7 |
Explain the dynamic instability of microtubules.
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- The "+" end is fast growing whereas the "-" end is slow growing.
-Dimers add more easily...
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| 8 |
-What is the growth rate of microtubule proportional to?
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-Concentration of GTP-tubulin dimers
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| 9 |
-What are the different configurations of microtubule, their functions, and where can...
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-Singlets, which carry and move vesicles, organelles, etc.
-Doublets, which make up cilia...
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| 10 |
-What makes up a singlet? protofilament?
-How many triplets are found in the microtubule organizing...
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-A singlet is made up of 13 protofilaments
- A protofilament is a single vertical column of...
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| 11 |
Where are the "-" ends of microtubules found?
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-Anchored in MTOC
-near nucleus, where t he microtubules radiate out towards the cell periphery
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| 12 |
What are the functions of the kinesin and dynein motor proteins?
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-Kinesin carries material towards the "+" end (anterograde)
-Dynein carries material towards...
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| 13 |
What is the function and location of the gamma tubulin?
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-It serves as a scaffold for growth in the MTOCs where it organizes cilia and flagella.
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| 14 |
-In the centrosome, how are the centrioles oriented?
-What are basal bodies?
-Where do the...
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-Centrioles are oriented 90 degrees from one another?
-Basal bodies are MTOCs of cilia and...
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| 15 |
-What are centrioles made up of and what do they contain?
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-They are made up of 9x triplet MT as well as containing gamma-tubulin.
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