Flashcard Set Preview
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Topical Anesthesia1. mucous membranes-42. intact skin3. cut skin
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1. bronch, endoscopy, nasal surgery, intubation2. IV start, skin grafting, circumcision3. lac...
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Tumescent Anesthesia1. med used2. EBL/ analgesia?
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1. Lidocaine (0.1% or less) with Epi (1:1000000)2. 12ml bld loss/ L of fat removed18-24hrs...
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TachyPhylaxis1. def2. way to prevent?3. thot to be d/t what?
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1. repeated injection of same dose produces dcrs response2. short dosing intervals so pain...
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Metabolism1. estersa. pathwayb. slowest/ fastest2. amidesa. pathway and 1st stepb. dependent...
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1a. hydrolysis of ester bond by plasma cholinesteraseb. slow- tetra. fast- chloroprocaine2a....
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1. what will signif prolong Lidocaine's half life3. rapidly cleared?4. 2 with interned clearance?5....
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1. hepatic dysfunction2. Renal disease3. chloroprocaine4. Lidocaine, Mepivacaine5. Bupivacaine,...
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Lung Extraction1. pulmonary extraction of which amide LA's?2. for Bupivacainea. pulm extraction...
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1. Lidocaine, prilocaine, Bupivacaine2a. dose-dependent/ saturableb. beta blockers (propranolol)
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**VERY few True allergies**1. most common true allergy with esters is r/t what?2. no _____...
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1. PABA2. cross-sensitivity3. preservative
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Absorption of LA1. 2 things that will incr absorption systemically?2. 3 things that will dcrs...
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1. if site is very vascular and incr dose (linear relationship btw dose and plasma lvls)2....
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1. relationship btw concentration and bound drug (r/t protein binding)2. fetal trapping of...
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1. incr concentration= incr % of free drug, lower % of bound drug2. fetus- acidotic; drug trapped...
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Incidences of TNS after spinal anesthesia1. occurs more frequently with which drugs?2. which...
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1. Lidocaine and Mepivacaine2. lithotomy, knee arthroscopy
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Local Toxicity1. exposure of ___ nerve to high concent of LA in lab resulted in injury2. 2...
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1. desheathed2. spinal cord and nerve root (peripheral nerve block - safe)3. nerve that is...
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1. 3 S/S or components of neurotoxicity2. Transient neurological symptomsa. symptomsb. occurs...
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1. non-specific patchy numbnessTNSCaudal Equina Syndrome2a. moderate to severe pain in lower...
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1. 3 signif factors that pre-dispose pt to TNS
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1. patient positioningneural ischemia secondary to stretchmaldistribution of LA (pooling......
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Cauda Equina SYndrome1. diffuse injury across ___ ___ resulting in varying degrees of what...
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1. lumbosacral plexus/ sensory loss, bladder/ bowel dysfunction, paraplegia-- toxicity of LA2....
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1. LA and BBB2. dose-dependent pattern of symptomsa. low plasma concentrationsb. higher concentrationsc....
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1. readily cross BBB2a. CNS depressionb. CNS excitation (seizures)c. generalized CNS depression
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Factors in CNS Toxicity1. potential approx parallels ____2. what will increase the potential...
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1. drug potency2. acidosisincr PCO2dcrs Pro bindingdcrs clearancerapid IV injection3. BZD,...
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1. potential for CNS toxicity varies with type of block= how?2. likelihood of unintentional...
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1. ICE BS2. peripheral nerve block
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1. cardiac or CNS toxicity requires higher plasma concentrations?2. potential for cardiac toxicity...
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1. cardiac2. potency3. high lipid solub/ high potency4. bradycardia, hypotension, hypoxia
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Lidocaine vs Bupivacaine1. myocardial contractility2. elctrophysiologic effects3. higher affinity...
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1. equal2. Bupiv produces greater3. Bupivacaine
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1. TH for bupivacaine induced cardiotox is reduced in what condition?- patient's taking what?2....
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1. pregnancy- BB, CCB, diogixin2a. inhibition of nucleus tracts solitarii in medulla - inhibition...
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1. compare Ropivacaine/ Levobupivacaine with Bupiva. equipotent for which 2 procedures?b. when...
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1. the exhibit 30-40% lower potential for systemic toxicitya. plexus anesthesia and nerve blockb....
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1. good way to prevent cardiotoxicity2. other than ACLS stuff, what may be good treatment for...
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1. appropriate dose** frequent aspiration of fractional injection**2. Lipid infusion (drug...
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a
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a
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