Liver, Gallbladder and Hepatobiliary Secretion

Aka portal triadislands in CT septa w/ branches of hepatic artery, portal vein, bile duct, lymphatic and occasionally nerve

Hepatocytes: large polyhedral cells with central (possibly binucleate) nuclei arranged in anastomosing sheets called muralia

Modified tight junctions: only have zonula occludens and macula adherens

Sinusoids (discontinuous capillaries which have discontinuous endothelium and no true basal lamina)

Phagocytic cells in the endothelial lining and bulging into the lumen of sinusoids

Small space b/w hepatocytes and endothelium where hepatocytes take up nutrients and release proteins (ENDOCRINE!)

Ito or fat-storing cells scattered throughout the sinusoids w/ vitamin A-rich lipid deposits

Enters at porta hepatis via hepatic artery and portal vein --> sinusoids --> central veins --> hepatic vein --> IVC

20-30% oxygenated blood from hepatic artery70-80% nutrient rich blood from portal vein

Liver lymph

Produce serum proteinsuptake chylomicronscontrol blood glucosedetoxform bile and bile pigments

Bile

Small lumen in the junction b/w two hepatocytes

Secreted into canaliculi --> muralia --> Canals of Herring (duct w/ duct cells and hepatocytes) --> pre-ductules (all duct cells) --> small bile ducts in portal tracts --> two main bile ducts --> hepatic duct + cystic duct --> common bile duct

Low cuboidal to tall columnar