Flashcard Set Preview
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| 1 |
What proportion of liver cells are hepatocytes?What percent of liver volume do they take up?
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60%78%So they are relatively high volume relative to other cells
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| 2 |
What does the RER do?
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Protein synthesis
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| 3 |
What does the SER do?
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P450 oxidationDrug metabolismFA metabolismCholesterol
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What do the mitochondria do?
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Oxidative phosphorylationFA oxidationKrebs cycleUrea cycle
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What do lysosomes do?
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Digestion and catabolism both of of self and exogenous products (e.g. copper)
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| 6 |
What do peroxisomes do?
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FA ox.Alcohol metabolism
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| 7 |
Name 2 precursors of glucose in gluconeogenesis
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pyruvatelactate
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| 8 |
Name 3 pathways Glucose-6-P can enter
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Pentose PhosphateGlycolysisGlycogen synthesis
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| 9 |
Name 3 pathways that pyruvate can enter
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Krebs cycleFA synthesis (via Ac CoA)AA synthesis (via Oxaloacetic acid)
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| 10 |
What is lactose metabolized into?Fructose?
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galactosefructose 1,6 BisP
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| 11 |
What is the relationship btw. cirrhosis and carbohydrate metabolism?What type of liver disease...
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Insulin resistance (hyperglycemia)Acute liver failure (hypoglycemia)
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| 12 |
What is the distribution of lipids in chronic liver disease?Cholestatic LD?
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1. HypertriglyceridemiaLDL, HDL and TC decrease2. TC and TG elevatedproduction...
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| 13 |
Name 3 effects of excess alcohol metabolism
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Increased FA synthesisDecreased B-oxidationDecreased VLDL synthesis
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| 14 |
Name the 2 primary bile acidsName the 3 secondary bile acids
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Primary: Cholic acid, Chenodeoxyholic acidSecondary: Deoxycholic acid, Lithocholic acid, Ursodeoxycholic...
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| 15 |
What are the 2 ways to excrete NH4+?
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Urea cycleGlutamine synthetase takes up NH4+, glutaminase gets rid of it in urine as NH3
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