KNES 433 MT 2 (16) SLIDES

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KNES 433 MT 2 (16) SL

Created Nov 21, 2010
by aftonw

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	Side A	Side B
1	- _____ surrounds the platelet plug, creating a ______ mesh	fibrin
2	______ is fored that dissolves fibrin --> blood clot is slowly removed	plasmin
3	- play a role in cardiovascular angiogenesis - ex. plasminogen, plasmin	hemostatic proteins
4	- precursor to plasmin - prevents clots	plasminogen
5	- tisssue plasminogen activator (tPA) - fibrinolytic enzyme	plasmin
6	tPA can be increased with	exercise
7	2 pathways that lead to the formation of a fibrin clot	1. intrinsic pathway 2. extrinsic pathway
8	the intrinsic and extrinsic pathways converge on a _____ pathway that leads to clot formation...	common
9	the formation of a red thrombus (a clot) in response to an abnoral vessel wall hemostatis	intrinsic pathway
10	fibrin clot formation in response to tissue injury-trauma	extrinsic pathway
11	- a coagulation protein that has many effects in the coagulation cascade - a serine protease...	thrombin (factor II)
12	factors that convert prothrombin to thrombin (2)	1. factor X 2. factor V
13	- inactivated state of thrombin - produces in the liver	prothrombin
14	- vitamin K dependent protein synthesized hepatocytes	prothrombin
15	- exposed with injury - initiates a cascade of biochemical reactions - conversion of prothrombin...	tissue factor (TF)
16	- the liver must be bale to use _______ to produce factors II, VII, IX, and X	vit K
17	the liver needs vit K to produce factors (4)	1. F II 2. F VII 3. F IX 4. F X
18	______ is generated at a site of vascular damage	thrombin
19	- activates blood platelets and endothelial cells	thrombin
20	platelets adhere to damaged endohelial cells and to each other, forming a ______	thrombus
21	- growth factors (ie. platelet-derived growth factor, at the site of damage) - promoting tissue...	activated plateletes
22	1st part coagulation cascade (8)	vascular constriction --> limits blood flow to injured area --> platelets become activated ...
23	2nd part of the coagulation cascade ()	activated platelets change shape to accommodate the formation of the plug --> fibrin mesh...
24	plug containing only platelets	white thrombus
25	plug containing platelets and RBC	red thrombus
26	partial thromboplastin (PTT) test measures	protein factors that are part of the intrinsic and common pathways
27	intrinsic and common pathway protein factors (10)	1. XII 2. XI 3. IX 4. VIII 5. X 6. V 7. II 8. fibrinogen 9. prekallikrein (PK) 10....
28	the prothrombin (PT) test measures	the factors that make up he extrinsic and common pathways
29	factors that make up the extrinsic and common pathways (5)	1. VII 2. X 3. V 4. II 5. fibrinogen
30	the 2 screening tests that help diagnose defect/deficiencies in coagulation factors	1. partial thromboplastin test (PTT) 2. prothrombin test (PT)
31	______ cells dominate early lesions	immune
32	_________ molecules accelerate lesion progression	immune effector
33	activation of inflammation elicits	acute coronary syndromes
34	an inflammatory disease in which immune mechanisms interact with metabolic risk factors to...	atherosclerosis
35	quiescent plaque process: marker: (2)	process: plaque formation marker: cholesterol, LDL
36	vulnerable plaque process:(5) marker: (4)	process: inflammation, multiple factors, infection?, rupture, macrophages? marker: c-reactive...
37	rupture, platelet-thrombin micro emboli process: (3)	process: thrombosis, platelet activation, thrombin