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celiac disease
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T-lymphocyte mediated auto-immune disorder triggered only in the small intestinal mucosa by...
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effect of gluten diet on celiac disease
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improves when on a gluten-free diet and relapses when gluten is reintroduced
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immune response in celiac disease
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cell mediated response: inflammatory response, gluten-sensitive CD4+ recognize gluten derived...
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characteristic of the intestine that severity of celiac disease depends
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length of intestine involved
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classical presentation of celiac
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1-5 yo, biggest symptom is diarrheamay also have constipation, vomiting, failure to thrive,...
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health problems associated with delayed presentation of celiac disease
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rickets, Fe deficient anemia, personality problems, short stature
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pathogenesis of anemia
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Fe absorbed in duodenum/jejunumfolic acid absorbed in jejunumB12 absorbed in ileum
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pathogenesis of osteoporosis
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Ca absorbed in duodenum/jejunumvit D malabsorbed if fat is malabsorbed
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pathogenesis of steatorrhea
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absorption of fat requires brush border enzymes, and fat-soluble vitamins will not be absorbed
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cystic fibrosis
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defect in CFTR that affects electrolyte and water secretion in pancreatic duct cells so duct...
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percent of normal pancreatic enzyme activity when CF manifests clinically
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less than 10
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medical problems associated with CF
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fat soluble vitamin deficiencies, hypoalbuminemia, edema, anemia, pneumonia, respiratory disease
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diagnostic methods for CF
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sweat chloride testdiagnose pancreatic exocrine insufficiency
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