Inflammation and Tissue Repair

1. Inflammation phase 2. Proliferation phase 3. Maturation phase

It's the first phase of healing. prepares the wound for healing Lasts 1-6 days from injury

Second phase of healing. rebuilds the damaged structures and strengthenes the wound Lasts 3-20 days from injury

3rd phase of healing modifies the scar tissues into its mature form, 9 on (1-2 years) This timeline does not apply to every injury because more factors could affect the healing process ex) size, nutrition, medications, other infections etc.

1.vasoconstriction 2. vasodilation 3. clot formation 4. phagocytosis

1.epitheliaziation 2. fibroplasias/ collagen production 3. wound contracture 4. neovascularization

1. Synthesis/ lysis balance, 2. Collagen fiber orientation, 3. Healed injury

It's an immediate protective response attempt to destroy dilute or isolate the cells or agents that may be at fault.

Heat Calor Increase vascularity swelling Tumor blockage of lymphatic drainage pain Dolar physical pressure of chemical irritation of pain sensitive redness Rubor increase vascularity

Latin : factio laesa pian and swelling

Increase vascular permeablity, edema

Recruitment/ stimulation of inflammatory cells, acute inflammation PMSs, platelets; chronic inflammation - macrophages, lymphocytes, plasmas cells

Thrombus formation, vasoactive mediators (vascular permeability)

Predominate and release a number of factors that amplify the platelet aggregation response, initiate a coagulation cascade or act as chemoattractants for cells involved in the inflammatory phase.

Replace neutrophils after 2 days from injury