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Related Flashcards
Cards In This Set
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What is an example of an adrenergic neuron-blocking agent?
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Reserpine (prototype), guanethidine, guanadrel
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What is the MOA of Reserpine?
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Depletion of norepinephrine from post ganglionic sympathetic neurons, effect on the CNS: sedation, state of indifference to environment
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What is Reserpine used for?
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HTN, psychotic states
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What are some adverse effects of Reserpine?
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Depression, cardiovascular effects (bradycardia, orthostatic hypotension, nasal congestion), increased GI activity
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What are some examples of a Centrally Acting Alpha 2 Agonist?
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Clonidine, methyldopa, and methyldopate, others: guanabenz, guanfacine
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What is the MOA of clonidine?
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Selective activation of Alpha 2 in CNS, reduces sympathetic outflow ...results in decreased CO and BP, & vasodilation
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What is clonidine used for?
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HTN and relief of severe pain (cancer)
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What are some adverse effects of clonidine?
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Drowsiness, xerostomia (dry mouth), rebound HTN (response to sudden withdrawal), NOT for pregnant women
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What is the MOA of methyldopa & methlydopate?
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Similar to clonidine BUT it must be converted in the brainstem to be an effective alpha 2 agonist, decreases BP, causes vasodilation
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What is methyldopa and methyldopate used for?
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Only approved for HTN
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What are the adverse effects of methyldopa/methyldopate?
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Positive comb's test, 5% of positive develop hemolytic anemia, test prior to treatment...hepatotoxicity
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