Flashcard Set Preview
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| 1 |
Effect of Heterozygosity and Phase on Detecting Recombination Effects:
1. Detecting recombination...
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1. that a parent be heterozygous at both loci, and that we know which allele at locus 1 is...
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| 2 |
Effect of Heterozygosity and Phase on Detecting Recombination Effects:
1. what is phase?
2....
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1In an individual who is heterozygous at two syntenic loci, one with alleles D and d, the other...
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Linkage and Recombination Frequency:
1. What is linkage?
2 Analysis of linkage depends on...
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1. Linkage is the term for a departure from the independent assortment of two loci. The tendency...
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GENETIC MAPS
1. What is the map distance between two loci?
2. What is the unit of measurement...
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1. The theoretical concept based on data; extent of observed recombination (theta) between...
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As the map distance between two loci increases, why does frequency of recombination NOT...
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Because the distance between 2 loci increases and the chance that the chromosome carrying these...
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1. When 2 loci are far enough apart, at least one _____ occurs during every _____
2. this...
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1. crossover; meiosis
2. independently; theta =0.5
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Linkage Equilibrium and Disequilibrium
1. Linkage disequilibrium : permits a higher resolution...
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1. inferring; millions of recombinations over thousands of generations, back to the origins...
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Linkage Equilibrium:
1. what is it ? example?
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1 Linkage equilibrium - when the frequency of each allele in the haplotypes is the same as...
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| 9 |
Linkage Equilibrium - example from book?
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TWO LOCI:
MARKER locus 1 with two alleles, A and a
DISEASE locus 2 with disease allele...
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| 10 |
At alow resolution of a few _________, the alleles at 2 loci of 1cM or more apart will not...
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centromeres. preferred phase
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| 11 |
In Linkage equilibrium, each haplotype is as ____________ in the population as one would expect...
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frequent; loci; haplotype
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| 12 |
What is a disease-containing haplotype?
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when disease allele first enters population, the set of alleles at markers linked to the disease...
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| 13 |
The degree to which the original disease-containing haplotype will persist over time depends...
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the probability that recombination can move the diisease allele OFF the original haplotype...
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| 14 |
The speed at which recombination will move the disease allele onto a new haplotype is the product...
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1. the number of generations (opportunities for recombination)
2. frequency of recombination...
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| 15 |
Linkage Disequilibrium - haplotypes not in linkage equilibrium.
1. From previous example -...
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1. allele D and allele a are in linkage diseqiulibrium
2. chromosomes carrying the disease...
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