Histology - Cartilage + Bone

Direct From Lecture Slides.
 
Created Dec 12, 2009
by ejberg
Table View
Download
Print

Flashcard Set Preview

Side ASide B
Cartilage
Connective tissue w/rigid extracellular matrix Chondrocytes (cells) with low metabolic...
From where does cartilage develop?
Mesenchyme
Cartilage development/growth
Develops from mesenchyme Chondroblasts for collagen fibrils Differentiation of...
Perichondrium
Sheath of dense irregular connective tissue – with fibroblasts and vasculature, envelops...
Interstitial growth
Mitotic division of existing chondrocytes and production of new matrix (young cartilage)
Appositional growth
Differentiation of new chondrocytes from stem cells (inner layer of perichondrium)...
Name the 3 forms of cartilage
Hyaline Elastic Fibrocartilage
Hyaline (glass) cartilage
Most common Type II collagen Appears blue/white In embryo: serves as skeleton...
Hyaline cartilage matrix
Amorphous ground substance with proteoglycans – including chondroitin sulfate and...
Hyaline cartilage chondrocytes
Chondrocytes occupy small cavities in matrix (lacunae) Surface of cell irregular;...
name the two kinds of bone growth
intramembranous ossificationendochondrial ossification
Lacunae
Small cavities in cartilage/bone matrix
Isogenous group / cell nests
Deeper round chondrocytes grouped – up to 8 cells – all offspring from same chondrocyte
Elastic cartilage
Support w/flexibility Auricle of ear, external auditory canal, Eustachian tube,...
Fibrocartilage
Tough support + tensile strength Intervertebral disks, tendon and ligament attachment...
Trabecular / cancellous /spongy bone
Slender irregular bars and sheets of bone, trabeculae, which branch and intersect...
Compact bone
No spaces or hollow space visible to the eye Thick-walled tube of the shaft (diaphysis)...
Haversian canals
Individual lamellae form concentric rings around larger longitudinal canals (50 micrometers...
Osteon
Haversian canals and surrounding lamellae
Volkmann’s (perforating) canals
From peristeal surfaces, Haversian canals enter the bone perpendicular to its long axis Communicate with...
Interstitial lamellae
Remnants of Haversian systems that have been partially destroyed Fills intervals...
Name the 2 lamella which run parallel to inner and outer surface of the bone, immediately...
1-       Circumferential lamellae 2-       Endosteal...
Formation of compact bone
Osteoblasts produce lamellae of bone matrix inward on the surface of longitudinal...
Intramembranous ossification
type of BONE GROWTH Primitive connective tissues layer that becomes vascularized Cells differentiate...
Endochondral ossification
type of BONE GROWTH transformation of cartilage (bone model) to osseous tissue periosteal bud...
epiphyseal plate
between the diaphysis and the epiphyses – a thin sheet of cartilage is maintained...
periosteal collar
consists of a thin sheet of woven bone deposited around shaft of the cartilage model formed during...
Decalcification of bone – tissue preparation
Cellular and organic components preserved and inorganic components removed by acid Then embedded,...
Ground bone – tissue preparation
Grining thin piece of bone with abrasives Matrix well preserved but cells are...
Periosteum
Layer of dense connective tissue Covers all bones except over articular surfaces
Endosteum
Thin layer of cell-rich connective tissue Lines the surface of marrow cavity/spaces
Osteoprogenitor cells
Stem cells of bone Located in periosteum and endosteum Hard to distinguish...
What components are responsible for bone’s hardness?
Cells (osteocytes) and intercellular matrix which contains organic compounds (collagen...
Lamellar structure
Bone matrix organized in layers
Lacunae
Cavities which contain cells
Canaliculi
Radiating from each lacuna, narrow channels that penetrate adjacent lamellae
Osteoblasts
Associated with bone formation Small cuboidal or pyramidal cells, form continuous...
Collagen fibers
Within lamellae Run parallel and oblique in adjacent lamellae
Osteocytes
Small inactive cells Isolated from each other in individual lacunae Cell processes...
Osteoclasts
Bone-restoring cells Multinucleated (5 to 10 per section) Giant cells (up...
Howship’s lacuna
small hollow excavation in matrix contains osteocytes
list the zones of cartilage at the zone of ossification that occur during endochondral...
reserve cartilage zone of chondrocyte proliferation zone of cartilage maturation...
reserve cartilage
Farthest away from the zone of ossification looks like immature hyaline cartilage
zone of chondrocyte proliferation
longitudinal columns of mitotically active chondrocytes
zone of cartilage maturation and hypertrophy
cells and lacunae grow in size
zone of cartilage calcification
forms border between cartilage and zone of bone deposition matrix stains deeply...
zone of retrogression
cartilage cells die matrix destroyed and vascular primary marrow extends into...
zone of ossification
osteoblasts differentiate from cells in the marrow tissue and gather on calcified...
zone of resorption
marrow cavities increase in size resorption of bone in diaphysis cavity forms...
bone remodeling
osteoclasts “drill” circular tunnel within existing bone matrix osteoblasts deposit...


Upgrade and get a lot more done!
Upgrade    Cancel