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Cards In This Set
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Define hematopoiesis
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The continuous formation and production of BCs and their development (including maturation, specialization, proliferation)
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What factors regulate hematopoiesis?
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Cytokines/Growth factors (glycoproteins)
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What stages of hematopoiesis do cytokines affect?
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Production (stimulate or inhibit), Differentiation, Maturation/Survival
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Give 2 examples of cytokines
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Interleukins, Colony stimulating factors (CSFs)
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What are interferons
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Cytokines that inhibit or slow hematopoiesis
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Describe the embryonic/fetal production of blood cells; include where production occurs
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20 days after fert. mesenchymal tissue lining yolk sac; 4 wks liver, spleen, thymus; 4 months bone marrow (and liver)
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Describe the production of blood cells in a child and an adult
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Occurs in the red marrow; for children in most skeletal bones; for adults select skeletal bones; also in the lymph nodes
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List 3 properties of stem cells
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Can self-renew via CK stimulated mitosis; Differentiate via CK; Die via interferon initiated apoptosis
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Describe 5 characteristics or trends that tend to occur as cells age
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Cell size decreases; N/C decreases as nucleus condenses; nucleoli disappear; cytoplasm gets lighter; granules appear
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Describe the granulocytic maturation series (6 cells)
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Myeloblast, Promyelocyte, Myelocyte, Metamyelocyte, Band, Mature
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 ID this cell; are there nucleoli? granules? |
Myeloblast; Y nucleoli; no granules
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 ID this cell; are there nucleoli? granules? what else is significant about this cell? |
Promyelocyte; nucleoli Y; many red/ppl granules; has some ltd motility
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 ID this cell; are there nucleoli? granules? what is diff about the nucleus? what else is significant about this cell |
Myelocyte; oval eccentric nucleus w flattened side; no nucleoli; 1 and 2 granules; light blue cyto; last cell capable of mitosis
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 ID this cell; what is diff about the nucleus? are there nucleoli? granules? |
Metamyelocyte; indented kidney bean shape nucleus; pink cyto; 2 granules and some 3
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 ID this cell; what is diff about the nucleus? what else is significant about this cell? |
Band granulocyte; c-shaped nucleus w uniform width; full motility
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