Gram Negative Bacteria

Srict anaerobe, nonfermentative but oxidizes amino acids as energy sources, coccobacillus, sensitive to dessication,

Requires charcoal, starch, blood, or albumin to grow- fastidious organism

B. parapertusis( mild pertussis) and B. bronchiseptica( pneumonia)

Highly contagious, resembles common cold, peak number of bacteria,

Repetitive coughing, loss of clilated cells, mucous clearance impaired, whooping terminates with vomiting, immune response is pretty active

Bacteria diminish, secondary complications

Binds to galactose residues on sulfated glycolipids commonly expressed on ciliated cells

S2 subunit binds to glycolipids of ciliated cells and phagocytes. Results in increase in cAMp which increases mucous production, decreased phagocytosis, chemotaxis, and oxidative burst

Peptidoglycan fragment that directly detroys ciliated epithelial respiratory cells and stimulates release of IL-1

Transmission through respiratory droplets

PCR, Culture from a oropharngeal swab of a Bordet-gengou media

Facuative anaerobe, ferments carbs, requires Nad and hemin to grow, coccobacillus

Pneumonia, epiglottis, and meningitis

Pilus, capsule( b being the worst), Low MW glycoprotein, IGA protease

Transmission through respiratory route and direct contact