GASTROENTERITIS

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Gastroenteritis: most common symtpoms? (4)
Diarrhea****
Nausea
Vomiting
Abdominal pain
Main ways to get gastro?
Ingesting contaminated food or drink...or swimming/bathing in contaminated water
What pathogens can cause gastro?
Bacteria, viruses, and protozoans
Most commonly encountered viral pathogens?
Norovirus, rotavirus, astrovrius, and enteric adenovirus
Imp pediatric cause of gastro?
Rotavirus
Which virus is responsible for most adult gastro?
Norovirus
Mechanism of norovirus?
Directly infect cells of the small intestine, resulting in alteration of the mucosa architecture (notably shortening or loss of the microvilli), causing diarrhea on teh basis of malabsportion. short-lived illness (24-48 hrs)
Most commonly find protozoan infections in which people?
Travelers and people who may bed exposed to untreated water (eg: hikers)
2 most common protozoan pathogens?
Entamoeba histolytica and giardia lamblia
Entamoeba histolytica invades where? Causes what?
Invades colon. Causes bloody diarrhea
Giardia lamblia invades wehre?
Invades small intestine. causes a malabsoprtive syndrome and an osmotic diarrhea.
Major bacterial pathogens in U.S.? (3)
Salmonella adn Campylobacter jejuni and Shigella
Most common bacterial diarrhea amongst travelers?
Enterotoxigenic E. coli
Mechs that bacteria can --> gastro?
*direct invasion of the mucsoa with tissue destrcution adn inflammation
*growth of bacteria within the bowel lmen with toxin prdouction and release
*adherence (but not invasion) of the bacteria to the mucosal surface with interference of the normal absoprtive process without tissue destruction
*production of a toxin during bacterial growth in food or water, which is then ingested preformed
Food hx to ask about?
All foods in last 48 hrs + changes in dietary habits, like earitn at resutaurants or picnics