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Sergiline/Deneprenyl and Rasalagine MOA?
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Selegiline and rasalagine selectively inhibit MAO-B and prevent the breakdown of dopaminine...
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use of Selegiline
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-used as a supplement to LDOPA, particularly in the latter stages of parkinsonism.
-decreases...
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use of rasalagine
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new drug approved for use in both early and late stages of parkinsons
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side effects of selegiline/deneprenyl and rasalagine?
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-side effects are similar to LDOPA but les severe
-tremor, dyskinesias, choreiform movements
-hallucinations,...
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Entacapone and Tolcopone MOA
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-inhibit metabolism of dopamine and LDOPA by COMT>provide sustained blood levels of LDOPA.
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Entacapone and tolcaphone uses?
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-used in conjunction with LDOPA and LDOPA plus carbidopa for tx of parkinsons
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entacapone and tolcapone adverse effects?
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-se are due to increased levels of dopamine and other cetecholamines>hallucinations, nausea,...
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Stalevo
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new combination product that contains:
LDOPA, Carbidopa, and entacapone
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uses of anticholinergic drugs? (benztropine and trihexyphenidyl)
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-mild parkinsons, usually more effective agains tremor than rigidity.
-drug of choice for...
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side effects of anticholinergic drugs?(benztropine and trihexyphenidyl)
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-automatic: dry mouth, dry, hot skin, hyperthermia, constipation, urine retention, loss of...
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antihistamines (diphenhydramine)-benadryl use?
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effectiveness in parkinsonism is primarily due to anticholinergic activity
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what drugs are used in mild-moderate treatment of parkinsons(primary/idiopathic)
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amantadine, dopamine agonists, MAO-B inhibitors, or anticholinergics>generally less effective...
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what drugs are used in treatment of moderate-severe symptoms of idiopathic/primary parkinsons?
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LDOPA and carbidopa with or without entacapone
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what is your treatment of non-responsive patients in primary/idiopathic parkinsons?
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add a dopamine agonist, seligiline, amantadine or anticholinergic
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what is the deal with the early use of seligeline?
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some experts advocate its early use, but this evidence is controversial and the drug is not...
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what is the deal with the early use of pramipexole?
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some experts recomend LDOPA and carbidopa therapy started early in the course of the disease,...
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treatment of iatrogenic parkinsonism cuased by antipsychotic drugs, reserpine or metoclopramide?
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stop or decrease dose of drug, add anticholinergic for more rapid reversal
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