Flashcard Set Preview
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| 1 |
cell type/cancer for vimentin stain
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connective tissue/sarcoma (mesenchyme origin)
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| 2 |
cell type/cancer for desmin stain
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muscle/rhabdo or leio
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| 3 |
cell type/cancer for cytokeratin stain
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epithelial/carcinoma (epithelial origin)
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| 4 |
cell type/caner for neurofilament stain
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neurons/neuroblastoma or primitive neuroectodermal tumor
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| 5 |
mechanism of spread of epithelial and mesechymal tumors
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e: lymphaticsm: hematogenous
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| 6 |
neoplasm assoc w/ down syndrome
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AML and ALL
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| 7 |
neoplasm assoc w/ XP and albinism
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SCC>basal cell and melanoma skin cancers
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| 8 |
neoplasm assoc w/ tuberous sclerosis
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cardiac rhabdomyoma, astrocytoma, angiomyolipoma
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| 9 |
neoplasm assoc w/ Paget's disease of bone
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secondary osteosarcoma or fibrosarcoma
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| 10 |
neoplasm assoc w/ immunodeficiency states
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malignant lymphomas
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| 11 |
neoplasm assoc w/ AIDS
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aggressive, malignant, non-Hodgkin lymphomas and Kaposi's sarcoma
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| 12 |
neoplasm assoc w/ acanthosis nigrans
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visceral malignancy of stomach, lung, breast, uterus
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| 13 |
neoplasm assoc w/ radiation exposure
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sarcoma, papilary thyroid cancer
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| 14 |
cancer assoc w/ mutation in the following oncogenes:N-mycretc-kit
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neuroblastomaMEN II and IIIgastrointestinal stromal tumor
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| 15 |
cancer assoc w/ mutation in p16 tumor suppressor gene
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melanoma
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| 16 |
cancers to follow w/ CEA
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colorectalpancreatic gastricbreast
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| 17 |
cancers to follow w/ CA-125
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ovarian and malignant epithelial tumors
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| 18 |
cancers to follow w/ S-100
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melanoma, neural tumors, astrocytomas
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| 19 |
cancers to follow w/ bombesin
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neuroblastoma, lung, and gastric cancer
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| 20 |
cancers to follow w/ tartrate-resistant acid phosphatase
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hairy cell leukemia
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| 21 |
cancers to follow w/ CA-19-9
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pancreatic adenocarcinoma
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| 22 |
toxic effects of CCl4
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centrilobular necrosis and fatty change of the liver
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| 23 |
toxic effects of arsenic
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SCC of the skin and liver angiosarcoma
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| 24 |
toxic effects of alkylating agents
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leukemia
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| 25 |
toxic effects of radon
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lung cancer
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| 26 |
disease causing paraneoplastic ADH release
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small cell lung cancer or CNS disorders
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| 27 |
diseases causing paraneoplastic PTH-RP release
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squamous cell lung cancer, renal cell carcinoma, breast carcinoma
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| 28 |
diseases causing paraneoplastic EPO production
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renal cell carcinoma, hemangioblastoma, HCC, pheo
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| 29 |
cancers w/ psammoma bodies
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"PSaMMoma"papillary (thyroid)serous (ovarian)meningiomamesothelioma
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| 30 |
diseases w/ a decreased ESR
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sickle cell (altered shape can't form roleaux)polycythemia (too many)CHF
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| 31 |
primary cancers that metastasize to the brain
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"Lots of Bad Stuff Kills Glia"LungBreastSkin (melanoma)KidneyGI
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| 32 |
primary cancers that metastasize to the liver
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Cancer Sometimes Penetrates Benign LiverColonStomachPancreasBreastLung
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| 33 |
primary cancers that metastasize to bone
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prostate, thyroid, testes, breast, lung, kidney
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| 34 |
most common and most deadly cancers in men
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incidence: prostate, lung, colonmortality: lung, prostate, colon
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| 35 |
most common and most deadly cancers in women
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incidence: breast, lung, colonmortality: lung, breast, colon
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| 36 |
cnacers assoc w/ K-RAS mutation
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colon, lung, pancreas
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| 37 |
cancers assoc w/ H-RAS mutation
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Hematuria --> kidney and bladder cancers
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| 38 |
cancers assoc w/ N-RAS mutations
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melanomas and hematologic malignancies
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| 39 |
cancer assoc w/ clonarchis sinesis
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biliary cancer
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| 40 |
mechanism of etoposide
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inhibition of topoisomerase II
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| 41 |
mechanism and toxicity of busulfan
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DNA alkylator that cause pulmonary fibrosis
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| 42 |
mechanism and side effects of bleomycin
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induces free radicals that cause strand breaks in DNASE: pulmonary fibrosis
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| 43 |
mechanism of 6-merceptopurine
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purine analog that inhibits PRPP and blocks de novo purine synthesis
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| 44 |
cancer drugs that are metabolized by xanthine oxidase
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6-mercaptopurine and 6-thioguanate
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| 45 |
mechanism and toxicity of cisplatin
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cross-links DNASE: nephro and ototoxic
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| 46 |
nitrogen mustard DNA alkylator
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cyclophsphamide
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| 47 |
methotrexate mechanism
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folic acid analog that inhibits DHFR
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| 48 |
paclitaxel mechanism
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prevents tubulin disassembly
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| 49 |
mechanism and toxicity of doxorubicin
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generates free radicals and non-covalently intercalates DNAcardiotoxic
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| 50 |
DNA alkylating agent used in brain cancer
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nitrosurease (-mustine)
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| 51 |
mechanism of vincristine
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prevents tubulin assembly
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| 52 |
mechanism of 5-fluorouracil
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inhibits thymidylate synthase --> decreased nt synthesis
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| 53 |
mechanism of tamoxifen
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SERM - blocks estrogen binding to ER (+) cells
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| 54 |
mechanism of cytarabine
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inhibits DNA Pol
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| 55 |
mechanism of traztuzumab
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monoclonal Ab against HER-2
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| 56 |
agent to reverse methotrexate toxicity
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leucovorin
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| 57 |
uses for methotrexate
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uterine pathologies
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| 58 |
tx for AML
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cytarabine
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| 59 |
imantinib
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Ab to BCR/ABL fusion tyr kinase --> tx for CML
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| 60 |
tx for testicular cancer
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Eradicate Ball Canceretoposidebleomycincisplatin
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| 61 |
topical tx for actinic keratosis and basal cell cancers
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5-fluorouracil
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| 62 |
tx for childhood tumors
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dactinomycin
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| 63 |
mechanism of hydroxyurea
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inhibits ribonucleotide reductase
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| 64 |
chemo agent causing hemorrhagic cystitis
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cyclphosphamide
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| 65 |
potential side effects of prednisone
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Chronic Prednisone Can Obviously Have Unintended Harmful Affects on ImmunityCushing-like sx,...
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| 66 |
thalamic nuclei for vision
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lateral geniculate nucleus
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| 67 |
thalamic nuclei for auditory
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medial geniculate nucleus
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| 68 |
thalamic nucleus for somatosensory input from the body
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VPL
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| 69 |
thalamic nucleus for trigeminothalamic and taste pathways to somatosensory cortex
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VPM
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| 70 |
thalamic nuclei that project from basal ganglia to the motor cortex
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ventral anterior and ventral lateral
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| 71 |
thalamic nuclei that integrates visual, auditory, and somesthetic input
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pulvinar nucleus
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