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CYP450 And Pgp Substrates, Inhibitors, And Inducers


The Drug Name Is On One Side And Whether It Is Substrate, Inducer, Or Inhibitor For Specific CYP450 Isoenzymes Is On The Back. If The Drug Was Listed As Both Substrate And Inhibitor, But It Wasn't Starred As A Substrate Then The Inhibitor Is In Bold And That's All We Need To Know. Also, The Subrates/inhibitors/inducers For Pgp Are Included
  
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Caffeine
 
Substrate, CYP1A2
Clozapine
 
Substrate, CYP1A2, CYP3A4
Olanzapine
 
Substrate, CYP1A2
Theophylline
 
Substrate, CYP1A2
Clomipramine
 
Substrate, CYP1A2, CYP2C19, CYP3A4
imipramine
 
Substrate, CYP1A2, CYP2C19, CYP3A4
amitriptyline
 
Substrate, CYP1A2, CYP2C19, CYP3A4
R-Warfarin
 
Substrate, CYP1A2
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haloperidol
 

Substrate, CYP1A2
Inhibitor, CYP2D6
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fluvoxamine
 

Substrate, CYP1A2
Inhibitor, CYP1A2, CYP2C9/10
phenytoin
 

Substrate, CYP2C9, CYP2C19
Inducer, CYP3A4
S-warfarin
 
Substrate, CYP2C9
clotrimazole
 
inducer for pgp
phenobarbital
 

Inducer for pgp
Trifluoperazine
 

inhibitor for pgp
Miscellaneous
propanolol
 

inhibitor for pgp
Cardiac drug
nicardipine
 

Inhibitor for pgp
Cardiac drug
nifedipine
 

Inhibitor for pgp
Cardiac drug
itraconazole
 

Inhibitor for pgp
Antibiotic
ceftriaxone
 

Inhibitor for pgp
Antibiotic
metoprolol
 
Substrate, CYP2D6
diazepam
 
Substrate, CYP2C19
desmethyldiazepam
 
Substrate, CYP2C19
lansoprazole
 

Substrate, CYP2C19
Inhibitor, CYP2C19
aldosterone
 

substrate for pgp
Steroid
omeprazole
 

Substrate, CYP2C19
Inhibitor, CYP2C19
dexamethasone
 

substrate for pgp
Steroid
propafenone
 
Substrate, CYP2D6
All TCAs
 
Substrate, CYP2D6
codeine
 
Substrate, CYP2D6
dextromethorphan
 
Substrate, CYP2D6
tramadol
 
Substrate, CYP2D6
atomoxetine
 
Substrate, CYP2D6
hydrocortisone
 

substrate for pgp
steroids
paroxetine
 

Substrate, CYP2D6
Inhibitor, CYP2D6
progesterone
 

substrate for pgp
inhibitor for pgp
Steroid
loperamide
 

substrate for pgp
miscellaneous
mitomycin
 

substrate for pgp
Chemotherapy agent
midazolam
 
Substrate, CYP3A4
Ca 2+ channel blockers
 
Substrate, CYP3A4
simvastatin
 
Substrate, CYP3A4
atorvostatin
 
Substrate, CYP3A4
lovastatin
 
Substrate, CYP3A4
cyclosporine
 
Substrate, CYP3A4
tacrolimus
 
Substrate, CYP3A4
ritonavir
 

Substrate, CYP3A4
Inhibitor, CYP2D6, CYP3A4
estrogens
 
Substrate, CYP3A4
pimozide
 
Substrate, CYP3A4
carbamazepine
 

Substrate, CYP3A4
Inducer, CYP3A4
paclitaxel
 

substrate for pgp
Chemotherapy agent
doxorubicin
 

substrate for pgp
Chemotherapy agent
indinavir
 

Substrate, CYP3A4
Inhibitor, CYP3A4
saquinavir
 

Substrate, CYP3A4
Inhibitor, CYP3A4
erythromycin
 

Substrate, CYP3A4
Inhibitor, CYP3A4
daunorubicin
 

substrate for pgp
Chemotherapy agent
quinine
 

Substrate, CYP3A4
Inhibitor, CYP3A4
vinca alkaloids
 

substrate for pgp
Chemotherapy agent
dactinomycin
 

substrate for pgp
Chemotherapy agent
digoxin
 

Substrate for pgp
Cardiac
fexofenadine
 

Substrate for pgp
Antihistamine
cimetidine
 
Inhibitor, CYP1A2, CYP2C19, CYP2D6
amiodarone
 
Inhibitor, CYP1A2, CYP2C9/10, CYP2D6
disulfiram
 
Inhibitor, CYP1A2, CYP2C9/10, CYP3A4
ciprofloxacin
 
Inhibitor, CYP1A2
levofloxacin
 
Inhibitor, CYP1A2
enoxacin
 
Inhibitor, CYP1A2
norfloxacin
 
Inhibitor, CYP1A2
zafirlukast
 
Inhibitor, CYP2C9/10
topiramate
 
Inhibitor, CYP2C19
fluoxetine
 
Inhibitor, CYP2D6
quinidine
 
Inhibitor, CYP2D6
bupropion
 
Inhibitor, CYP2D6
phenothiazines
 
Inhibitor, CYP2D6
terbinafine
 
Inhibitor, CYP2D6
diltiazem
 
Inhibitor, CYP3A4
clarithromycin
 
Inhibitor, CYP3A4
grapefruit juice
 
Inhibitor, CYP3A4
nefazodone
 
Inhibitor, CYP3A4
nelfinavir
 
Inhibitor, CYP3A4
ketoconazole
 
Inhibitor, CYP3A4
itraconazole
 
Inhibitor, CYP3A4
verapamil
 
Inhibitor, CYP3A4
tobacco
 
Inducer, CYP1A2
rifampin
 
Inducer, CYP2C9/10, CYP3A4
barbiturates
 
Inducer, CYP2C9/10, CYP3A4
St. John's Wort
 
Inducer, CYP3A4

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