CYP450 And Pgp Substrates, Inhibitors, And Inducers

88 cards

The Drug Name Is On One Side And Whether It Is Substrate, Inducer, Or Inhibitor For Specific CYP450 Isoenzymes Is On The Back. If The Drug Was Listed As Both Substrate And Inhibitor, But It Wasn't Starred As A Substrate Then The Inhibitor Is In Bold And That's All We Need To Know. Also, The Subrates/inhibitors/inducers For Pgp Are Included


 
  
Created Sep 20, 2009
by
umich pharm

 

 
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  Side A   Side B
1
Caffeine
 
Substrate, CYP1A2
2
Clozapine
 
Substrate, CYP1A2, CYP3A4
3
Olanzapine
 
Substrate, CYP1A2
4
Theophylline
 
Substrate, CYP1A2
5
Clomipramine
 
Substrate, CYP1A2, CYP2C19, CYP3A4
6
imipramine
 
Substrate, CYP1A2, CYP2C19, CYP3A4
7
amitriptyline
 
Substrate, CYP1A2, CYP2C19, CYP3A4
8
R-Warfarin
 
Substrate, CYP1A2
9
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10
haloperidol
 
Substrate, CYP1A2 Inhibitor, CYP2D6
11
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12
fluvoxamine
 
Substrate, CYP1A2 Inhibitor, CYP1A2, CYP2C9/10
13
phenytoin
 
Substrate, CYP2C9, CYP2C19 Inducer, CYP3A4
14
S-warfarin
 
Substrate, CYP2C9
15
clotrimazole
 
inducer for pgp
16
phenobarbital
 
Inducer for pgp  
17
Trifluoperazine
 
inhibitor for pgp Miscellaneous
18
propanolol
 
inhibitor for pgp Cardiac drug
19
nicardipine
 
Inhibitor for pgp Cardiac drug
20
nifedipine
 
Inhibitor for pgp Cardiac drug
21
itraconazole
 
Inhibitor for pgp Antibiotic
22
ceftriaxone
 
Inhibitor for pgp Antibiotic
23
metoprolol
 
Substrate, CYP2D6
24
diazepam
 
Substrate, CYP2C19
25
desmethyldiazepam
 
Substrate, CYP2C19
26
lansoprazole
 
Substrate, CYP2C19 Inhibitor, CYP2C19
27
aldosterone
 
 substrate for pgp Steroid
28
omeprazole
 
Substrate, CYP2C19 Inhibitor, CYP2C19
29
dexamethasone
 
substrate for pgp Steroid
30
propafenone
 
Substrate, CYP2D6
31
All TCAs
 
Substrate, CYP2D6
32
codeine
 
Substrate, CYP2D6
33
dextromethorphan
 
Substrate, CYP2D6
34
tramadol
 
Substrate, CYP2D6
35
atomoxetine
 
Substrate, CYP2D6
36
hydrocortisone
 
substrate for pgp steroids
37
paroxetine
 
Substrate, CYP2D6 Inhibitor, CYP2D6
38
progesterone
 
substrate for pgp inhibitor for pgp Steroid  
39
loperamide
 
substrate for pgp miscellaneous
40
mitomycin
 
substrate for pgp Chemotherapy agent
41
midazolam
 
Substrate, CYP3A4
42
Ca 2+ channel blockers
 
Substrate, CYP3A4
43
simvastatin
 
Substrate, CYP3A4
44
atorvostatin
 
Substrate, CYP3A4
45
lovastatin
 
Substrate, CYP3A4
46
cyclosporine
 
Substrate, CYP3A4
47
tacrolimus
 
Substrate, CYP3A4
48
ritonavir
 
Substrate, CYP3A4 Inhibitor, CYP2D6, CYP3A4
49
estrogens
 
Substrate, CYP3A4
50
pimozide
 
Substrate, CYP3A4
51
carbamazepine
 
Substrate, CYP3A4 Inducer, CYP3A4
52
paclitaxel
 
substrate for pgp Chemotherapy agent
53
doxorubicin
 
substrate for pgp Chemotherapy agent
54
indinavir
 
Substrate, CYP3A4 Inhibitor, CYP3A4
55
saquinavir
 
Substrate, CYP3A4 Inhibitor, CYP3A4
56
erythromycin
 
Substrate, CYP3A4 Inhibitor, CYP3A4
57
daunorubicin
 
substrate for pgp Chemotherapy agent
58
quinine
 
Substrate, CYP3A4 Inhibitor, CYP3A4
59
vinca alkaloids
 
substrate for pgp Chemotherapy agent
60
dactinomycin
 
substrate for pgp Chemotherapy agent
61
digoxin
 
Substrate for pgp Cardiac
62
fexofenadine
 
Substrate for pgp Antihistamine
63
cimetidine
 
Inhibitor, CYP1A2, CYP2C19, CYP2D6
64
amiodarone
 
Inhibitor, CYP1A2, CYP2C9/10, CYP2D6
65
disulfiram
 
Inhibitor, CYP1A2, CYP2C9/10, CYP3A4
66
ciprofloxacin
 
Inhibitor, CYP1A2
67
levofloxacin
 
Inhibitor, CYP1A2
68
enoxacin
 
Inhibitor, CYP1A2
69
norfloxacin
 
Inhibitor, CYP1A2
70
zafirlukast
 
Inhibitor, CYP2C9/10
71
topiramate
 
Inhibitor, CYP2C19
72
fluoxetine
 
Inhibitor, CYP2D6
73
quinidine
 
Inhibitor, CYP2D6
74
bupropion
 
Inhibitor, CYP2D6
75
phenothiazines
 
Inhibitor, CYP2D6
76
terbinafine
 
Inhibitor, CYP2D6
77
diltiazem
 
Inhibitor, CYP3A4
78
clarithromycin
 
Inhibitor, CYP3A4
79
grapefruit juice
 
Inhibitor, CYP3A4
80
nefazodone
 
Inhibitor, CYP3A4
81
nelfinavir
 
Inhibitor, CYP3A4
82
ketoconazole
 
Inhibitor, CYP3A4
83
itraconazole
 
Inhibitor, CYP3A4
84
verapamil
 
Inhibitor, CYP3A4
85
tobacco
 
Inducer, CYP1A2
86
rifampin
 
Inducer, CYP2C9/10, CYP3A4
87
barbiturates
 
Inducer, CYP2C9/10, CYP3A4
88
St. John's Wort
 
Inducer, CYP3A4

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