CYP450 And Pgp Substrates, Inhibitors, And Inducers

CYP450 And Pgp Substrates, Inhibitors, And Inducers The Drug Name Is On One Side And Whether It Is Substrate, Inducer, Or Inhibitor For Specific CYP450 Isoenzymes Is On The Back. If The Drug Was Listed As Both Substrate And Inhibitor, But It Wasn't Starred As A Substrate Then The Inhibitor Is In Bold And That's All We Need To Know. Also, The Subrates/inhibitors/inducers For Pgp Are Included
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Caffeine
 
Substrate, CYP1A2
Clozapine
 
Substrate, CYP1A2, CYP3A4
Olanzapine
 
Substrate, CYP1A2
Theophylline
 
Substrate, CYP1A2
Clomipramine
 
Substrate, CYP1A2, CYP2C19, CYP3A4
imipramine
 
Substrate, CYP1A2, CYP2C19, CYP3A4
amitriptyline
 
Substrate, CYP1A2, CYP2C19, CYP3A4
R-Warfarin
 
Substrate, CYP1A2
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haloperidol
 
Substrate, CYP1A2 Inhibitor, CYP2D6
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fluvoxamine
 
Substrate, CYP1A2 Inhibitor, CYP1A2, CYP2C9/10
phenytoin
 
Substrate, CYP2C9, CYP2C19 Inducer, CYP3A4
S-warfarin
 
Substrate, CYP2C9
clotrimazole
 
inducer for pgp
phenobarbital
 
Inducer for pgp
Trifluoperazine
 
inhibitor for pgp Miscellaneous
propanolol
 
inhibitor for pgp Cardiac drug
nicardipine
 
Inhibitor for pgp Cardiac drug
nifedipine
 
Inhibitor for pgp Cardiac drug
itraconazole
 
Inhibitor for pgp Antibiotic
ceftriaxone
 
Inhibitor for pgp Antibiotic
metoprolol
 
Substrate, CYP2D6
diazepam
 
Substrate, CYP2C19
desmethyldiazepam
 
Substrate, CYP2C19
lansoprazole
 
Substrate, CYP2C19 Inhibitor, CYP2C19
aldosterone
 
substrate for pgp Steroid
omeprazole
 
Substrate, CYP2C19 Inhibitor, CYP2C19
dexamethasone
 
substrate for pgp Steroid
propafenone
 
Substrate, CYP2D6
All TCAs
 
Substrate, CYP2D6
codeine
 
Substrate, CYP2D6
dextromethorphan
 
Substrate, CYP2D6
tramadol
 
Substrate, CYP2D6
atomoxetine
 
Substrate, CYP2D6
hydrocortisone
 
substrate for pgp steroids
paroxetine
 
Substrate, CYP2D6 Inhibitor, CYP2D6
progesterone
 
substrate for pgp inhibitor for pgp Steroid
loperamide
 
substrate for pgp miscellaneous
mitomycin
 
substrate for pgp Chemotherapy agent
midazolam
 
Substrate, CYP3A4
Ca 2+ channel blockers
 
Substrate, CYP3A4
simvastatin
 
Substrate, CYP3A4
atorvostatin
 
Substrate, CYP3A4
lovastatin
 
Substrate, CYP3A4
cyclosporine
 
Substrate, CYP3A4
tacrolimus
 
Substrate, CYP3A4
ritonavir
 
Substrate, CYP3A4 Inhibitor, CYP2D6, CYP3A4
estrogens
 
Substrate, CYP3A4
pimozide
 
Substrate, CYP3A4
carbamazepine
 
Substrate, CYP3A4 Inducer, CYP3A4
paclitaxel
 
substrate for pgp Chemotherapy agent
doxorubicin
 
substrate for pgp Chemotherapy agent
indinavir
 
Substrate, CYP3A4 Inhibitor, CYP3A4
saquinavir
 
Substrate, CYP3A4 Inhibitor, CYP3A4
erythromycin
 
Substrate, CYP3A4 Inhibitor, CYP3A4
daunorubicin
 
substrate for pgp Chemotherapy agent
quinine
 
Substrate, CYP3A4 Inhibitor, CYP3A4
vinca alkaloids
 
substrate for pgp Chemotherapy agent
dactinomycin
 
substrate for pgp Chemotherapy agent
digoxin
 
Substrate for pgp Cardiac
fexofenadine
 
Substrate for pgp Antihistamine
cimetidine
 
Inhibitor, CYP1A2, CYP2C19, CYP2D6
amiodarone
 
Inhibitor, CYP1A2, CYP2C9/10, CYP2D6
disulfiram
 
Inhibitor, CYP1A2, CYP2C9/10, CYP3A4
ciprofloxacin
 
Inhibitor, CYP1A2
levofloxacin
 
Inhibitor, CYP1A2
enoxacin
 
Inhibitor, CYP1A2
norfloxacin
 
Inhibitor, CYP1A2
zafirlukast
 
Inhibitor, CYP2C9/10
topiramate
 
Inhibitor, CYP2C19
fluoxetine
 
Inhibitor, CYP2D6
quinidine
 
Inhibitor, CYP2D6
bupropion
 
Inhibitor, CYP2D6
phenothiazines
 
Inhibitor, CYP2D6
terbinafine
 
Inhibitor, CYP2D6
diltiazem
 
Inhibitor, CYP3A4
clarithromycin
 
Inhibitor, CYP3A4
grapefruit juice
 
Inhibitor, CYP3A4
nefazodone
 
Inhibitor, CYP3A4
nelfinavir
 
Inhibitor, CYP3A4
ketoconazole
 
Inhibitor, CYP3A4
itraconazole
 
Inhibitor, CYP3A4
verapamil
 
Inhibitor, CYP3A4
tobacco
 
Inducer, CYP1A2
rifampin
 
Inducer, CYP2C9/10, CYP3A4
barbiturates
 
Inducer, CYP2C9/10, CYP3A4
St. John's Wort
 
Inducer, CYP3A4
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