CYP450 and pgp substrates, inhibitors, and inducers

88 cards

The drug name is on one side and whether it is substrate, inducer, or inhibitor for specific CYP450 isoenzymes is on the back. If the drug was listed as both substrate and inhibitor, but it wasn't starred as a substrate then the inhibitor is in bold and that's all we need to know. Also, the subrates/inhibitors/inducers for pgp are included


 
  
Created Sep 20, 2009
by
umich pharm

 

 
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  Side A   Side B
1
Caffeine
 
Substrate, CYP1A2
2
Clozapine
 
Substrate, CYP1A2, CYP3A4
3
Olanzapine
 
Substrate, CYP1A2
4
Theophylline
 
Substrate, CYP1A2
5
Clomipramine
 
Substrate, CYP1A2, CYP2C19, CYP3A4
6
imipramine
 
Substrate, CYP1A2, CYP2C19, CYP3A4
7
amitriptyline
 
Substrate, CYP1A2, CYP2C19, CYP3A4
8
R-Warfarin
 
Substrate, CYP1A2
9
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10
haloperidol
 

Substrate, CYP1A2

Inhibitor, CYP2D6

11
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12
fluvoxamine
 

Substrate, CYP1A2

Inhibitor, CYP1A2, CYP2C9/10

13
phenytoin
 

Substrate, CYP2C9, CYP2C19

Inducer, CYP3A4

14
S-warfarin
 
Substrate, CYP2C9
15
clotrimazole
 
inducer for pgp
16
phenobarbital
 

Inducer for pgp

 

17
Trifluoperazine
 

inhibitor for pgp

Miscellaneous

18
propanolol
 

inhibitor for pgp

Cardiac drug

19
nicardipine
 

Inhibitor for pgp

Cardiac drug

20
nifedipine
 

Inhibitor for pgp

Cardiac drug

21
itraconazole
 

Inhibitor for pgp

Antibiotic

22
ceftriaxone
 

Inhibitor for pgp

Antibiotic

23
metoprolol
 
Substrate, CYP2D6
24
diazepam
 
Substrate, CYP2C19
25
desmethyldiazepam
 
Substrate, CYP2C19
26
lansoprazole
 

Substrate, CYP2C19

Inhibitor, CYP2C19

27
aldosterone
 

 substrate for pgp

Steroid

28
omeprazole
 

Substrate, CYP2C19

Inhibitor, CYP2C19

29
dexamethasone
 

substrate for pgp

Steroid

30
propafenone
 
Substrate, CYP2D6
31
All TCAs
 
Substrate, CYP2D6
32
codeine
 
Substrate, CYP2D6
33
dextromethorphan
 
Substrate, CYP2D6
34
tramadol
 
Substrate, CYP2D6
35
atomoxetine
 
Substrate, CYP2D6
36
hydrocortisone
 

substrate for pgp

steroids

37
paroxetine
 

Substrate, CYP2D6

Inhibitor, CYP2D6

38
progesterone
 

substrate for pgp

inhibitor for pgp

Steroid

 

39
loperamide
 

substrate for pgp

miscellaneous

40
mitomycin
 

substrate for pgp

Chemotherapy agent

41
midazolam
 
Substrate, CYP3A4
42
Ca 2+ channel blockers
 
Substrate, CYP3A4
43
simvastatin
 
Substrate, CYP3A4
44
atorvostatin
 
Substrate, CYP3A4
45
lovastatin
 
Substrate, CYP3A4
46
cyclosporine
 
Substrate, CYP3A4
47
tacrolimus
 
Substrate, CYP3A4
48
ritonavir
 

Substrate, CYP3A4

Inhibitor, CYP2D6, CYP3A4

49
estrogens
 
Substrate, CYP3A4
50
pimozide
 
Substrate, CYP3A4
51
carbamazepine
 

Substrate, CYP3A4

Inducer, CYP3A4

52
paclitaxel
 

substrate for pgp

Chemotherapy agent

53
doxorubicin
 

substrate for pgp

Chemotherapy agent

54
indinavir
 

Substrate, CYP3A4

Inhibitor, CYP3A4

55
saquinavir
 

Substrate, CYP3A4

Inhibitor, CYP3A4

56
erythromycin
 

Substrate, CYP3A4

Inhibitor, CYP3A4

57
daunorubicin
 

substrate for pgp

Chemotherapy agent

58
quinine
 

Substrate, CYP3A4

Inhibitor, CYP3A4

59
vinca alkaloids
 

substrate for pgp

Chemotherapy agent

60
dactinomycin
 

substrate for pgp

Chemotherapy agent

61
digoxin
 

Substrate for pgp

Cardiac

62
fexofenadine
 

Substrate for pgp

Antihistamine

63
cimetidine
 
Inhibitor, CYP1A2, CYP2C19, CYP2D6
64
amiodarone
 
Inhibitor, CYP1A2, CYP2C9/10, CYP2D6
65
disulfiram
 
Inhibitor, CYP1A2, CYP2C9/10, CYP3A4
66
ciprofloxacin
 
Inhibitor, CYP1A2
67
levofloxacin
 
Inhibitor, CYP1A2
68
enoxacin
 
Inhibitor, CYP1A2
69
norfloxacin
 
Inhibitor, CYP1A2
70
zafirlukast
 
Inhibitor, CYP2C9/10
71
topiramate
 
Inhibitor, CYP2C19
72
fluoxetine
 
Inhibitor, CYP2D6
73
quinidine
 
Inhibitor, CYP2D6
74
bupropion
 
Inhibitor, CYP2D6
75
phenothiazines
 
Inhibitor, CYP2D6
76
terbinafine
 
Inhibitor, CYP2D6
77
diltiazem
 
Inhibitor, CYP3A4
78
clarithromycin
 
Inhibitor, CYP3A4
79
grapefruit juice
 
Inhibitor, CYP3A4
80
nefazodone
 
Inhibitor, CYP3A4
81
nelfinavir
 
Inhibitor, CYP3A4
82
ketoconazole
 
Inhibitor, CYP3A4
83
itraconazole
 
Inhibitor, CYP3A4
84
verapamil
 
Inhibitor, CYP3A4
85
tobacco
 
Inducer, CYP1A2
86
rifampin
 
Inducer, CYP2C9/10, CYP3A4
87
barbiturates
 
Inducer, CYP2C9/10, CYP3A4
88
St. John's Wort
 
Inducer, CYP3A4

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