CYP450 And Pgp Substrates, Inhibitors, And Inducers

The Drug Name Is On One Side And Whether It Is Substrate, Inducer, Or Inhibitor For Specific CYP450 Isoenzymes Is On The Back. If The Drug Was Listed As Both Substrate And Inhibitor, But It Wasn't Starred As A Substrate Then The Inhibitor Is In Bold And That's All We Need To Know. Also, The Subrates/inhibitors/inducers For Pgp Are Included
Created Sep 20, 2009
by umich pharm
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Side ASide B
Caffeine
Substrate, CYP1A2
Clozapine
Substrate, CYP1A2, CYP3A4
Olanzapine
Substrate, CYP1A2
Theophylline
Substrate, CYP1A2
Clomipramine
Substrate, CYP1A2, CYP2C19, CYP3A4
imipramine
Substrate, CYP1A2, CYP2C19, CYP3A4
amitriptyline
Substrate, CYP1A2, CYP2C19, CYP3A4
R-Warfarin
Substrate, CYP1A2
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haloperidol
Substrate, CYP1A2 Inhibitor, CYP2D6
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fluvoxamine
Substrate, CYP1A2 Inhibitor, CYP1A2, CYP2C9/10
phenytoin
Substrate, CYP2C9, CYP2C19 Inducer, CYP3A4
S-warfarin
Substrate, CYP2C9
clotrimazole
inducer for pgp
phenobarbital
Inducer for pgp  
Trifluoperazine
inhibitor for pgp Miscellaneous
propanolol
inhibitor for pgp Cardiac drug
nicardipine
Inhibitor for pgp Cardiac drug
nifedipine
Inhibitor for pgp Cardiac drug
itraconazole
Inhibitor for pgp Antibiotic
ceftriaxone
Inhibitor for pgp Antibiotic
metoprolol
Substrate, CYP2D6
diazepam
Substrate, CYP2C19
desmethyldiazepam
Substrate, CYP2C19
lansoprazole
Substrate, CYP2C19 Inhibitor, CYP2C19
aldosterone
 substrate for pgp Steroid
omeprazole
Substrate, CYP2C19 Inhibitor, CYP2C19
dexamethasone
substrate for pgp Steroid
propafenone
Substrate, CYP2D6
All TCAs
Substrate, CYP2D6
codeine
Substrate, CYP2D6
dextromethorphan
Substrate, CYP2D6
tramadol
Substrate, CYP2D6
atomoxetine
Substrate, CYP2D6
hydrocortisone
substrate for pgp steroids
paroxetine
Substrate, CYP2D6 Inhibitor, CYP2D6
progesterone
substrate for pgp inhibitor for pgp Steroid  
loperamide
substrate for pgp miscellaneous
mitomycin
substrate for pgp Chemotherapy agent
midazolam
Substrate, CYP3A4
Ca 2+ channel blockers
Substrate, CYP3A4
simvastatin
Substrate, CYP3A4
atorvostatin
Substrate, CYP3A4
lovastatin
Substrate, CYP3A4
cyclosporine
Substrate, CYP3A4
tacrolimus
Substrate, CYP3A4
ritonavir
Substrate, CYP3A4 Inhibitor, CYP2D6, CYP3A4
estrogens
Substrate, CYP3A4
pimozide
Substrate, CYP3A4
carbamazepine
Substrate, CYP3A4 Inducer, CYP3A4
paclitaxel
substrate for pgp Chemotherapy agent
doxorubicin
substrate for pgp Chemotherapy agent
indinavir
Substrate, CYP3A4 Inhibitor, CYP3A4
saquinavir
Substrate, CYP3A4 Inhibitor, CYP3A4
erythromycin
Substrate, CYP3A4 Inhibitor, CYP3A4
daunorubicin
substrate for pgp Chemotherapy agent
quinine
Substrate, CYP3A4 Inhibitor, CYP3A4
vinca alkaloids
substrate for pgp Chemotherapy agent
dactinomycin
substrate for pgp Chemotherapy agent
digoxin
Substrate for pgp Cardiac
fexofenadine
Substrate for pgp Antihistamine
cimetidine
Inhibitor, CYP1A2, CYP2C19, CYP2D6
amiodarone
Inhibitor, CYP1A2, CYP2C9/10, CYP2D6
disulfiram
Inhibitor, CYP1A2, CYP2C9/10, CYP3A4
ciprofloxacin
Inhibitor, CYP1A2
levofloxacin
Inhibitor, CYP1A2
enoxacin
Inhibitor, CYP1A2
norfloxacin
Inhibitor, CYP1A2
zafirlukast
Inhibitor, CYP2C9/10
topiramate
Inhibitor, CYP2C19
fluoxetine
Inhibitor, CYP2D6
quinidine
Inhibitor, CYP2D6
bupropion
Inhibitor, CYP2D6
phenothiazines
Inhibitor, CYP2D6
terbinafine
Inhibitor, CYP2D6
diltiazem
Inhibitor, CYP3A4
clarithromycin
Inhibitor, CYP3A4
grapefruit juice
Inhibitor, CYP3A4
nefazodone
Inhibitor, CYP3A4
nelfinavir
Inhibitor, CYP3A4
ketoconazole
Inhibitor, CYP3A4
itraconazole
Inhibitor, CYP3A4
verapamil
Inhibitor, CYP3A4
tobacco
Inducer, CYP1A2
rifampin
Inducer, CYP2C9/10, CYP3A4
barbiturates
Inducer, CYP2C9/10, CYP3A4
St. John's Wort
Inducer, CYP3A4

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