Flashcard Set Preview
| Side A | Side B | ||
| 1 |
Components of membrane attack complex?
|
C6-9
|
|
| 2 |
C1q?
|
Binds the Fc region of antibody/antigen complexes
|
|
| 3 |
Classical pathway?
|
Triggered by antibody bound to antigen, expose binding site for C1q.C1q has 6 globular heads...
|
|
| 4 |
C2b?
|
small fragment no known bioactivity
|
|
| 5 |
Lectin pathway?
|
MBL is a 6-headed protein similar to C1q which binds mannose.Bound and stabilised MBL interacts...
|
|
| 6 |
MASP 1 and 2 analogous to?
|
C1r and C1s
|
|
| 7 |
Opsonins C3b and C4b covalent binding?
|
- thioester bond protected by C3a- when cleavage occurs highly unstable reactive intermediate...
|
|
| 8 |
The alternative pathway?
|
C3 is a major plasma protein that is spontaneously activated by surface contactIs constantly...
|
|
| 9 |
Amplification?
|
1 C3 convertase can generate 1000 C3b opsonin moleculesSome bacteria also bind a plasma protein...
|
|
| 10 |
C5 convertase and the effector end of complement?
|
The two surface bound complexes C4b2a and C3bBb can cleave both more C3 and also cleave soluble...
|
|
| 11 |
Why doesn't complement attack normal cells?
|
- soluble C4b and C3b are very unstable. Thioester 1/2 life milliseconds. Only active when...
|
|
| 12 |
Serpin?
|
C1 inhibitor - binds to activated C1r,s removing it from C1q
|
|
| 13 |
C4BP?
|
binds C4b displacing C2a and destabilising C4b2a
|
|
| 14 |
Factor H?
|
Binds C3b displacing Bb. Cofactor for factor I
|
|
| 15 |
Factor I?
|
protease which cleaves C3b and C4b
|
|
| 16 |
DAF?
|
membrane protein that displaces Bb
|
|
| 17 |
CR1?
|
displaces C2a inactivating the C3 convertase
|
|
| 18 |
Properdin?
|
additional protein that binds to bacteria and accelerates the alternate pathway by stabilising...
|
|
| 19 |
Anaphylatoxins?
|
Extremely potent peptides produced from complement activation. C5a the most potentReceptors...
|
|
| 20 |
C5a activities?
|
Binds to C5a R on mast cell and endothelial cellsinduces SM contractionpotent chemokineincrease...
|
|
| 21 |
Complement deficiencies?
|
Late stage C5-9 deficiencies - susceptibility to Neisseria speciesC1i Hereditary angioneurotic...
|
No comments yet! Be the first to add a comment below!
Please login to post comments.
After login, we will forward you back to this flashcard.