Cholinergic/Adrenergic Agonists and Antagonists

A list of cholinergic (muscarinic and nicotinic) as well as adrenergic (alpha family and beta family) agonists and antagonists.

37 cards   |   Total Attempts: 182
  

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Cards In This Set

Front Back
Propranolol clinical use
Angina pectoris. Reduces cardiac work and O2 consumption by beta adrenergic receptor ANTAGONISM.
Non-selective A1 and A1 adrenergic blocker.
Phentolamine; phenoxybenzamine
Non-selective B1 and B2 (also B3) adrenergic blocker
Propranolol
A1 selective blocker
Prazosin
B1 (cardio) selective blocker
Metoprolol; atenolol
Older drugs ending with "sin"
Older drugs ending with "olol"
Sin=Alpha blocker
olol=beta blocker
Pheochromocytoma (adrenal medulla tumor which increases blood pressure).
Treat with phentolamine to block A1 receptors which will decrease cardiac output, force of contraction, and lower blood pressure.
Blocking A2 receptors leads to?
Answer 8
Greater quantities of NE in the synapse
Propranolol is a non-selective beta blocker, what are its affects?
Decrease HR, decreases contractility (negative inotrope) decreases renin release (B1 receptor in kidney) leading to decreased angiotensin which leads to decreased aldosterone which decreases blood pressure. Watch out for syncope!

Blocks relaxation of bronchial smooth muscle, watch out for bronchospasm.

blocks lipolysis and glycogenolysis (B3)
Some clinical uses of Propranolol:
Migraine headache prophylactic treatment
Arrhythmias
Pheochromocytoma (leading to high bp)
thyrotoxicosis
reduced mortality post MI.
Propranolol side effects:
Dizziness, nausea, depression, vivid dreams, fatigue, impotence.
May have severe rash, purpura, fever.
Chronic use leads to Type 2 diabetis, increased VLDL and decreased HDL.

In diabetics it delays recovery from hypoglycemia.
Propranolol contraindications:
ASTHMA! It's a Beta blocker so lung smooth muscle won't dilate.
Cardiogenic shock; 2nd or 3rd degree heart block.
COPD
Isoproterenol
Beta 2 agonist.
All B1-selective drugs lose ________ at high doses
Selectivity. Be cautious in using in asthma patients. Use in MI patients with COPD; may also be preferable in diabetics.

Metoprolol (Lopressor) is prototype.
Acetylcholine, nicotine, and bethanechol are:
ACh is nicotinic and muscarinin receptor agonist (all cholinergic)
Nicotine is a nicotinic agonist only
Bethanechol is muscarinic agonist only.