cholinergic drugs & cholinergic blockers

32 cards

chapter 20 & 21 - cholinergic and cholinergic blockers


 
  
Created Mar 12, 2011
by
ekvidera

 

 
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1
acetylcholine
 
neurotransmitter of the PSNS
2
acetylcholinersterase
 
the enzyme responsible for breaking down acetylcholine
3
nicotinic receptors
 
located in the ganglia of both PSNS and SNS, stimulated by alkaloid nicotine
4
muscarininc receptor
 
located postsynaptically in the effect organs of the PSNS, stimulated by the alkaloid muscarine
5
direct-binding cholinergic agonists
 
bind to cholinergic receptors, activating them
6
indirect-acting cholinergic agonists
 
inhibit the enzyme acetylcholinerstase, which breaks down ACh
7
reversible
 
bind to cholinesterase for a period of a few minutes to hours
8
irreversible 
 
bind to cholinesterase and form a permanent covalent bond
9
miosis
 
constriction of the pupil
10
Alzheimer's treatment
 
acetylcholine effects and stimulates muscarinic receptors - donepezil (Aricept)
11
donepezil (Aricept)
 
indirect-acting cholinergic drug used to treat Alzheimer's
12
bethanechol
 
direct-acting cholinergic used to treat urinary retention
13
in-direct acting drugs
 
drugs that cause skeletal muscle contraction
14
myasthenia gravis
 
muscle disease that breaks down the acetylcholine resulting in muscle weakness
15
adverse effects of cholinergics
 
result of overstimulation of the PSNS
16
two important adverse effects of cholinergics
 
hypotension and bradycardia
17
nursing implication of cholinergics
 
therapeutic effects of anti-Alzheimer's drugs may not occur for up to 6 weeks
18
cholinergic effect on intestine & bladder
 
increased gastric secretions, increased GI motility, increased urinary frequency
19
cholinergic effects on cardiovascular
 
decreased heart rate, vasodilation
20
receptors effected at recommended doses of cholinergics
 
muscarinic
21
receptors effected at high doses of cholinergics
 
nicotinic
22
parasympatholytics
 
drugs that block or inhibit the actions of acetylcholine in the parasympathetic nervous system
23
mechanism of cholinergic blockers
 
block the action of the NT acetylcholine at the muscarininc receptors in the parasympathetic...
24
mydriasis
 
dilation of the pupil
25
drug of choice for bradycardia
 
atropine
26
cardiovascular drug effect of cholinergic blocker
 
increased heart rate
27
Parkinson's treatment
 
cholinergic blockers because decreased muscle rigidity and tremors - benztropine (Cogentin)
28
benztropine (Cogentin)
 
drug used for treatment of Parkinson's disease
29
atropine
 
prototype cholinergic blocker
30
ipratropium (Atrovent)
 
inhaler - cholinergic blocker
31
classic side effect of cholinergic blocker
 
decreased salivation
32
nursing implication for cholinergic blocker
 
dry mouth may occur --> chew gum, frequent mouth care, hard candy


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