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Cards In This Set
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Acetylcholine
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Neurotransmitter of the PSNS
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Acetylcholinersterase
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The enzyme responsible for breaking down acetylcholine
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Nicotinic receptors
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Located in the ganglia of both PSNS and SNS, stimulated by alkaloid nicotine
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Muscarininc receptor
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Located postsynaptically in the effect organs of the PSNS, stimulated by the alkaloid muscarine
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Direct-binding cholinergic agonists
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Bind to cholinergic receptors, activating them
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Indirect-acting cholinergic agonists
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Inhibit the enzyme acetylcholinerstase, which breaks down ACh
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Reversible
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Bind to cholinesterase for a period of a few minutes to hours
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Irreversible
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Bind to cholinesterase and form a permanent covalent bond
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Miosis
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Constriction of the pupil
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Alzheimer's treatment
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Acetylcholine effects and stimulates muscarinic receptors - donepezil (Aricept)
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Donepezil (Aricept)
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Indirect-acting cholinergic drug used to treat Alzheimer's
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Bethanechol
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Direct-acting cholinergic used to treat urinary retention
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In-direct acting drugs
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Drugs that cause skeletal muscle contraction
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Myasthenia gravis
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Muscle disease that breaks down the acetylcholine resulting in muscle weakness
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Adverse effects of cholinergics
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Result of overstimulation of the PSNS
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