Flashcard Set Preview
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What are lipoproteins?
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1. macromolecular complex of proteins and cholesterol, cholesterol esters, triglycerides, phospholipids....
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Apoproteins
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A specific protein that is integrated into a lipoprotein complex
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What is VLDL? LDL? HDL?
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VLDL -- very low density lipoprotein is made in the liver to ship lipids to peripheral tissue....
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Two sources of cholesteryl Ester
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1. Inside cells, ACAT, transfers Fatty Acyl to cholesterol2. In circulation: transacylation...
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How do lipoproteins circulate in the blood?
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1. Chylomicrons are released from intestine and go to liver. 2. VLDL's are released from...
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How is LDL trafficked into cells?
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1. LDL with ApoB-100 binds to receptors (binding is pH dependent)2. Lyosomal activity releases...
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What are the parts of the LDL receptor?
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1. LDL binding site (CYS rich) (N-terminal)2. Epidermal Growth Factor (pH sensor?)3. O-linked...
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How is cholesterol regulated?
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1. LDL receptor (transcription and protease (PCSK9 which binds to EGF and degrades it))2. HMG-CoA...
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How does transcription work?
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1. The LDL receptor genes have SRE (Sterol Regulated Elements) which have binding proteins...
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How is is the Sterol level being sensed?
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Low: you WANT COP II proteins. So, the proteins bind to meladl on the SCAPHigh: Cholesterol...
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What is the role of SREBP in regulation of lipid metabolism?
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SREBP-2 regulates cholesterol, while SREBP-1 regulates triacylglycerides and phospholipids...
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How does statin work?
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1. Blocks cholesterol synthesis (HMG-CoA reductase)2. This effect means that the body produces...
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