Chemical Classification of Hormones

38 cards

chemical clas sificati


 
  
Created Dec 11, 2009
by
dockdance14

 

 
Table View
 
Download
 
Print

Flashcard Set Preview

  Side A   Side B
1
Endocrine System
 

-Endocrine glands (ductless) secrete hormones

 

2
Hormones
 
intercellular chemical messengers that are secreted into the blood and each target cells thru...
3
Chemical classes of hormones
 

1. Amines

 

2. Proteins and Peptides

 

3. Steroids

4
Amines
 

-derivative of tyrosine

 

* Thyroid Hormones

-T3 and T4 (secretes...

5
Thyroid Gland
 

-anterior neck

-circular arrangement of epithelial cells surround thyroid follicle;...

6
Synthesis of T3 and T4 in Thyroid Gland
 

-Uptake of I- from blood and transport thru epithelial cells of thyroid follicles into follicular...

7
Storage of T3 and T4 in Thyroid Gland
 

-Thyroglobulin is the colloid in follicular lumen

-Thyrogloblin = storage form of...

8
Release of T3 and T4 from Thyroid Gland
 

-Endocytosis of thyroglobulin by thyroid follicular cells

-Intracellular hydrolysis...

9
Transport of T4 and T3 in Blood
 

-Binding to thyroxine-binding globulin (TBG)

-Most T3 and T4 in blood are in bound...

10
Intracellular Actions of T4 and T3 in Target Cells
 

-Carrier-mediated uptake of T3 and T4 into target cells

-T4 converted to T3 by intracellular...

11
Actions of Thyroid Hormone on Target Tissues
 

-Target tissues = all tissues in body, except RBCs (no nucleus)

 

Actions:

- stimulation...

12
Symptoms of Hypothyroidism
 

-Low BMR

-Cold intolerance

-Weight gain

-Lethargy

-Slow...

13
Symptoms of Hyperthyroidism
 

-High BMR

-Heat intolerance

-Weight loss

-Hyperactivity

-Rapid...

14
Catecholamines
 

Sources:

Adrenal medulla- norepinephrine (20%) and epinephrine (80%)

Hypothalamus-...

15
Catecholamine Receptors
 

Types:

-Adrenergic- NE and Epi

-Dopaminergic- Dop

 

Location:...

16
Actions of NE and Epi
 

Heart: stim HR and force of contraction (CO, BP)

 

Vascular smooth...

17
Actions of Dopamine
 

Ant Pit Gland: inhibits prolaction secretion

18
Snthesis of proteins
 

Preprohormone

Prohormone

Hormone

Hormone

19
Protein/Peptide hormones
 

-Most hormones

-Hypothalamus: most

-Post and Ant Pit: all

-GI system:...

20
Protein/Peptide Receptors
 

-Many types

-Location: plasma membranes (polar)

-Receptors: act as ion channels,...

21
Steroid Hormones
 

-derived from cholesterol

-highly nonpolar --> not stored

22
Adrenal Gland
 

Medulla = inner

Cortex = outer

 

1. Zona Glomerulosa- aldosterone

2....

23
Major Steroid Hormones of Adrenal Cortex
 

1. Corticosterone

2. Aldosterone

3. Cholesterol

4. Cortisol

5....

24
Types of Adrenocortical Steroids
 

1. Mineralcorticoids

-Actions on renal handling of minerals (Na and K)

-Aldosterone...

25
Transport of Adrenal Corticosteroids in Blood
 

-Binding to corticosteroid binding globulin (CBG)

-Most in blood are bound

-Only...

26
Intracellular Actions of Adrenal Corticosteroids in Target Cells
 

-Diffuse into target cells

-Receptors for corticosteroids are intracellular

-Hormone-receptor...

27
Actions of Normal Basal Concentrations of Cortisol on Target Tissues
 

-Permissive for catecholamine actions on vascular smooth muscle (bp)

-Permissive...

28
Actions of Stress Levels (Inc conc) of Cortisol on Target Tissues
 

-Enhanced vascular reactivity to catecholamines (bp)

-Enhanced actions on metabolism...

29
Gonadal Steroid Hormones
 

Males:

Androgens

   Testosterone

 

Females:

Estrogens

  ...

30
Males
 
Testes = testosterone
31
Female
 

Ovaries = predominant steroid varies w/ phase of menstrual cycle

Follicular phase...

32
Transport of Gondal Steroids in Blood
 

-Binding to sex hormone binding globulin (SHBG)

-Most are bound form

-Free...

33
Intracellular Actions of Gonadal Steroids on Target Tissues
 

-Diffuse into target cells

-Location = intracellular

-Hormone-receptor complexes...

34
Conversion of Gonadal Steroids to Active Forms in Some Target Cells in Male
 

Testosterone -> 5-alpha-Dihydrotestosterone

 

Testosterone ->...

35
Mechanism of Action of Hormones with Intracelullular Receptors
 

-Free hormone diffuses through cell (nonpolar)

-Receptors in nucleus

-Function...

36
Mechanism of Action of Hormones with Plasma Membrane Receptors
 

-Polar

-Receptors on plasma membranes

37
Regulation of Hormone Receptors
 

-By natural hormonal ligands: up and down reg

-By other hormones: permissive effects,...

38
Permissive Action of Thyroid Hormone on Epinephrine-Induced Lipolysis
 

Thyroid hormone = little effect

 

Epinephrine = min effect

 

TH...

No comments yet! Be the first to add a comment below!

Please login to post comments.
After login, we will forward you back to this flashcard.


Upgrade and get a lot more done!
Upgrade    Cancel