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The basic living, structural and functional unit of the body.
The study of cell structure and function
Parts of a Cell
*Plasma (cell) membrane *Cytoplasm (a)Cytosol (b)Organelles *Nucleus
Surrounds the cell and occurs as a LIPID bilayer (2 back to back lipid layers) with interspersed...
orient in a BILAYER to make the basic framework of the membrane. Represent 75% of membrane...
Help form an outer coat on the cell called the GLYCOCALYX.
STRENGTHENS the membrane and decrease membrane fluidity.
Largley determine what functiona a cell will perform and can vary from cell to cell.
If membrane proteins extend into or through cell membranes.
A water filled pore through which IONS can pass.
(carrie proteins) Move a certain POLAR chemical from one side to the other by CHANGING the...
BOND to a specific chemical in the extracellular (outside) fluid SIGNAL the cell to carry out...
Molecules (chemicals) that bond to a specific receptor. (Ex. insulin ligan binds to insulin...
Speed up chemical reactions
Cell indentity markers
(glycoproteins) Help cells RECOGNIZE each other.
anchor proteins of neighboring cells to each other or they anchor filaments to the plasma membrane.
Glycoproteins help form the GLYCOCALYX which allows cells to:
PROTECT itself from being digested. Become sticky to HOLD it to other cells. Hold a fluid layer...
The membrane allows SOME chemicals to pass through but prevents passage of others.
Selective Permeability. Of those that PASS through:
*Chemicals that dissolve in lipids are NONPOLAR, UNCHARGED molecules (O2, CO2 and others) and...
Membranes is flexible enough that it is SELF SEALS after being punctured.
(change over a space) The selective permeable membrane maintains different concentrations of...
The extracellular side is slightly POSITIVE and the cytosol side is slightly NEGATIVE.
The combined concentration and electrical gradients.
Passive Process: Diffusion
The movement of a chemical from an area of higher concentration to lower concentration...
The diffusion rate depends on the following:
STEEPNESS of the concentration gradient. TEMPEERATURE. the LARGER THE SURFACE AREA of the membrane...
The movement of a chemical through the phospholipids of a membrane from a HIGHER concentration...
The movement of a chemical through a TRANSPORTER or ION CHANNEL in the plasma membrane ...
The movement of water molecules through a plasma membrane from a HIGHER concentration ...
Water can move through the phospholipids or through channel proteins.
Water moves from an area of:
Lower solute to Higher solute
Osmosis occurs ONLY:
when the membrane is permeable to water but NOT to certain solutes.
The pressure that must be applied to prevent osmotic movement (water movement) across a membrane....
A membrane of a solutions ability to change the cells shape or tone by altering its water...
A solution is a 0.9% NACl solution, which is ISOTONIC to red blood cell (RBC).
Usually isotonic to prevent damage to RBCs.
can be used to treat cerebral edema (draws out water)
can be used to treat dehydration (gets more water to them)
Active transport (requires energy)
The cell uses ENERGY to move a chemical from a LOWER concentration to a HIGHER concentration...
SODIUM ION/ K ION PUMP aka:
NA+/K+ ATPase pump. It is found in all cell membranes and uses 40% of cells ATP (energy).
Primary active transport
The movement of a chemical across a membrane from lower concentration to higher concentration....
Secondary active transportation
SIMULTANEOUS movement of Na+ (or H+) and ANOTHER chemical. This depends on a Na+ (or...
Transporter protein that moves the other chemical in the SAME directions as Na+
Transporter protein that moves the other chemical in the OPPOSITE direction to...
The movement of a material by small membrane bound spheres (vesicles)
Materials move INTO the cell in a vesicle formed from the plasma membrane.
Receptor mediated endocytosis
A specific LIGAND bonds to its receptor on the cell which stimulates that cell to engulf that...
movement of SOLID particles into the cell by a vesicle.
Bulk phase endocytosis (pinocytosis)
Movements of FLUID with dissolved SOLUTES into the cell by a vesicle. NO recceptor proteins...
A vesicle fuses with the plasma membrane and releases its contents to the outside. (ex. Glands)
A substance is moved THROUGH a cell, into one side and out the oppisite side.
The fluid inside the cell. It surrounds the other structures. Composed mostly of water. The...
The are between the plasma membrane and the nucleus. It includes the cytosol and the organelles.
An internal network of protein filaments that serves to maintain cell's shape, move structures...
Serves as a center for organizing microtubules in dividing cells (mitotic spindle) and nondividing...
Long whip like appendages that serve in cell LOCOMOTION.
Short bristle like appendages, which serve to MOVE materials over the surface of a stationary...
Serve to directly produce the PROTEINS (sites for protein synthesis) *Tiny spheres that...
Rough endoplasmic reticulum
Studded with ribosomes and acts as a site for synthesis of PROTEINS and phospholipids. Extends...
Smoothe endoplasmic reticulum
Acts as the major site for synthesis of LIPIDS in general. It also detoxifies toxins.
4-6 stacked flattened membraneous sacs. Serves to process, package, and deliver proteins and...
Vesicles that contain DIGESTIVE enzymes to break down materials for the cell.
Vesicles that contain enzymes (oxidases) that DETOXIFY materials.
Breakdown UNNEEDED, DAMAGED, or FAULTY proteins in the cytosol. Failure of proteosomes function...
(Power House) Serves to produce ATP using energy from the breakdown of food (cell respiration)....
Cell Nucleus: Function
Nucleus contains the GENES which CONTROL the structure and many activities of the cell.
Cell Nucleus: Structure Nuclear Envelope
The double membrane that surrounds the nucleus, it has PORES that allow water and dissolved...
Smaller spheres in the nucleus that produces the RIBOSOMES.
A single long DNA molecule or two DNA's that are duplicated and attatched to each other .
Half of a duplicated chromosomes.
The material that is composed of DNA and histone proteins. (Chromosomes are composed of chromatin.)
A segment of DNA, which controls one or more TRAITS by coding for a certain polypeptide.
TOTAL genetic information carried in a cell or an organism (all of their genes)
Sequence of events invovled in PROTEIN SYNTHESIS.
DNA has a genetic message that is in the form of a SEQUENCE of nucleotide bases along the molecule....
The genetic information on the DNA is passed to a messenger RNA (mRNA) molecule. ...
The___of the gene unwinds and ____between the bases break.
DNA / bonds
A_____molecule forms off of one side of the DNA by matching their bases. In this process...
mRNA / mRNA / DNA / DNA / mRNA
Transcription is catalyzed by
the enzyme RNA POLYMERASE
Segmants of mRNA called ____ are cut out and remaining segmants called ____ are spliced together...
Introns / exons / nucleus / variety
Base sequence along the mRNA is used to MAKE a protein that has a CERTAIN SEQUENCE of...
Bonds with mRNA and move along it
Each Transfer RNA...
has a certain sequence of 3 BASES exposed at one end (anticodon), and at the other end contains...
As the ribosomes move along the ____ it helps the corresponding ____ BOND to each triplet of...
mRNA / tRNA / mRNA
The amino acid on the new tRNA forms a _______ with the amino acid next to it and the peptide...
Peptide Bond / tRNA
The cell carries on every life process EXCEPT devision.
Interphase consist of 3 phases:
G1, S, and G2
(Gap Phase 1) The cell produces new organelles to replace those that were lost tothe other...
(S=synthesis) The chromosomes are duplicated (new DNA is synthesized)
(Gap Phase 2) Proteins needed for cell division are produced.
(M=mitosis) Nucleus divides (mitosis) and the cytoplasm divides (cytokenesis)
Somatic Cell Division
(Mitosis) Occurs in all body cells except for those cells that directly produce gametes...
Each somatic cell devision produces:
2 daughter cells, each with the same number and kinds of chromosomes as the original mother...
2 of each kind of chromosome
What is the order of Somatic cell devision?
Prophase, Metaphase, Anaphase, Telephase
Chromosomes condense or thicken, Nuclear envelope dissapears, Nucleoli dissapear, Mitotic spindle...
Chromosomes line up in a single row along the middle of the cell.
Chromosomes seperate at their centromeres and one copy of each travels to a separate...
Chromosomes unwind into more diffuse structures, Nuclear envelope reappears, Nucleoli reappear,...
The division of a parents cell's cytoplasm and organelles. Begins in late Anaphase or early...
When cytokinesis is complete:
Proteins that increase in concentration in between cell divisions to activate other chemicals...
Cdks (Cyclin dependent protein kinases)
Proteins that stimulate replication of DNA, or prophase to begin.
A normal, genetically programmed cell death that occurs in cells scattered throughout a tissue.
A pathological cell death that results from tissue injury of many adjacent cells, and usually...
Function of Reproductive Cell Devision:
produces gametes that will unite to form a new individual in sexual reproduction.
What happens when the chromosomes number is cut in half in the gametes?
It serves to keep the chromosome number constant from generation to generation. * it also serves...
Meiosis involves 2 cell devisions:
Meiosis I and Meiosis II
During meiosis I:
The chromosomes number is cut in half and a major mechanism that produces genetic variation...
Some cells ( muscle, skeletal and nerve) are not replaced because:
they wont divide or divide a limited number of times.
at the ends of chromosomes which erode with each mitosis event. This contributes...
Loss of ______, ______ , due to glucose forming cross links between proteins.
______ damage cells by oxidizing (stealing e- s from) lipids, proteins, or nucleic acids.
as cells age, their cell identity markers sometimes change, which stimulates the immune repsonse...
An abnormal, out of control, division of cells. Growth is at expense of normal tissue.
excess tissue that develops from uncontrolled cell proliferation.
An abnormal growth of cells that has not spread.
An abnormal growth of cells that often has spread to other parts of the body.
The spread of cancer cells to other parts of the body.
What is the root cause of cancer?
Mutation in genes that normally control cell division, to form oncogenes. CARCINOGENS...
Produces an abnormal protein that stimulates cell devision or can produce a growth factor in...
Occurs to bring a regulator gene near a dormant oncogene to activate it.
Tumor suppressor genes
inhibit cell division, but if a mutation occurs to make them nonfunctional, then cancer can...
A virus may splice an oncogene into a cells _____ when it invades that cell.
The loss of tissue differention and function that is characteristics of most malignancies.
Decreased size of cells, with a subsequent decreased size of the affected tissue or organ;...
Alteration in size, shape and organization of cells due to chronic irritation or inflammation;...
Increased number of cells in a tissue due to increased frequency of cell division.
Increased size of cells without cell division.
The transformation of one type of cell into another