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in massive cardiac enlargement if dilated cardiomyopathy which AV valve is functional and which...
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mitral ok tricuspid bad.
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Causes for dilated cardiomyopathy?
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Alcoholobesitypregnancy (peripartum)post viral infectionchagas dxthiamine insufficiencycardiotoxic...
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Stuff/Drugs that are directly cardiotoxic and contribute to dilated cardiomyopathy
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alcohol, Adriamycin (doxorubin): a cancer chemotherapy
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what would you see histologically in dilated cardiomyopathy?
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myofiber hypertrophy and disarray, Lacy interstitial fibrosis
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Mutated proteins in dilated cardiomyopathy?
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cytoskeletal proteins: dystrophin, desminsarcomeric-myosin heavy chainmuscular-actin
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Peripartum cardiomyopathy aka?duration?can cause?
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-cardiomyopathy of pregnancy-extends from latter pregnancy up to 6 months after delivery-sudden...
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clinical complications in dilated cardiomyopathy
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-heart failure (b/c of enlargement)-cardiac arrhythmia: stretching affects nodal cells-pulmonary...
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cause of hypertrophic cardiomyopathy?
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100% genetic cause
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hypertrophic cardiomyopathy can cause?
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-functional aortic stenosis-obstruction of left ventricular outflow-idiopathic hypertrophic...
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mutant cardiac proteins in hypertrophic cardiomyopathy
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sarcomeric-hyosin heavy chain and light chaintroponins T and I muscular-actin
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clinical complications in hypertrophic cardiomyopathy?
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cardiac arrhythmiasudden cardiac death*especially prominent in young athletes*
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main causes of restrictive cardiomyopathyother causes?
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*cardiac amyloidosis and endocardial fibroelastosis*other: loeffler's endomyocarditis (eosinophilic)Davies'...
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what is cardiac amyloidosis?what does it do?
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-build up of abnormal fibril in heart muscle-stiffens myocardium and also impairs contractility...
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cardiac amyloidosis can be commonly see in what?
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multiple myeloma and age related senile amyloid
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Gross pathology of cardiac amyloidosis?
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has a firm waxy appearance
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histological findings of hypertrophic cardiomyopathy
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-disoriented, tangled, enlarged myofibers-interstitial and myocardial fibrosis
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*apple green birefringence with congo red stain*
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cardiac amyloidosis
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Endocardial fibroelastosis is a very rare disease for..?what is it?
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INFANTS AND YOUNG CHILDRENthickening and fibrosis of endocardium
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heart failure cells are? and seen in what condition?
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they are macrophages in the alveoliseen in left heart failure when blood backs up into the...
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arhythmogenic right ventricular hypertrophy-mode of inheritance-sudden death due to?-typically...
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-autosomal dominant-arrhythmia-YOUNGER PATIENTS
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naxos syndrome
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arrhythmogenic right ventricular cardiomyopathy + hyperkeratosis of palms
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Nutmeg liver-MOA-seen in what disease?
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-right side of heart doesnt work and blood backs up into systemic and portal circulation-Right...
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When RHF occurs alone it's called?
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Cor Pulmonale
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