Flashcard Set Preview
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clinical presentation of fibrocystic change
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most frequent (and occurs in a large percentage) in women between 20-40 yo often presenting...
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gross features of fibrocystic change
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dense, rubbery, fibrous tissue replacing normal breast tissue w/ multiple brown to blue cysts
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histological features of fibrocystic change
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dense fibrosis and mild epithelial hyperplasia --> two cell population of epithelial and...
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histologic features on a breast bx that are assoc w/ increased risk of developing breast carcinoma
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epithelial hyperplasia (moderate to florid)sclerosing adenosis/complex sclerosing lesionsmall...
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clinical features of fibroadenoma
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most common benign tumor of the female breastmore common before 30 but can occur up to menopause...
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gross features of fibroadenoma
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well-circumscribed network of narrow clefts, haphazardly distributed w/in the gray-white firm,...
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histologic features of fibroadenoma
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delicate fibrous stroma surrounding glands lined by epithelium
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phyllodes tumor
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another tumor w/ simultaneous proliferation of glands and stroma that has more atypical/malignant...
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dx necessary to have Paget disease of the nipple
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must have an underlying ductal carcinoma (either in situ or infiltrating)
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gross features of Paget disease
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skin of the nipple and areola is often fissure, ulcerated, and oozing surrounded by inflammatory...
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histologic features of Paget disease
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epidermis is invaded by malignant cells (large cells w/ abundant clear cytoplasm and hyperchromatic...
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acute mastitis
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infection w/ S. aureus during the first month of breast feeding that presents w/ fever, erythema,...
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periductal mastitis
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abscess formation due to keratinization and plug of the nipple ducts that can lead to a fistula...
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clinical presentation of mammary duct ectasia
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multiparous women in 5th or 6th decade w/ a ropey thickening/periarelor mass due to duct obstruction
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histological characteristics of mammary duct ectasia
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dilated periareolar ducts filled w/ necrotic material and surrounded by inflammation
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| 16 |
fat necrosis
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localized mass, half of the time due to traumanecrotic adipocytes, lipid filled macrophages,...
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benign epithelial lesions in the breast
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1. non-proliferative changes: fibrocystic change (cyst/fibrosis/adenosis)2. proliferative changes...
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sclerosing adenosis
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number of acini per terminal duct is increased to at least double the number in uninvolved...
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complex sclerosing lesion/radial scar
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components of sclerosing adenosis, papillomas, epithelial hyperplasiaradial scar is a subtype...
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intraductal papilloma
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usually benign papillary architecture (branching fibrovascular cores) that arises in large...
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histologic features of atypical ductal hyperplasia
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monomorphic population of luminal cells, evenly spaced in a solid or cribriform patternhistologically,...
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histology of atypical lobular hyperplasia
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identical to LCIS except that the cells do not fill or distend more than 50% of the acini w/in...
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risk factors for breast cancer
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age: peak is 75-80; most significant risk factorFHx: >1 first degree relative w/ breast...
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DCIS, comedo type
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ducts filled w/ necrosis surrounded by fibrosis st the necrotic cell membranes commonly calcify...
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DCIS, non-comedo type
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solid: cells filling and distorting lobulecribriform: cookie cutter spaces that may have calcificationspapillary:...
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clinical characteristics of lobular carcinoma in situ
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doesn't produce stromal fibrosis or calcifications --> almost always an incidental findingmore...
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histological features of LCIS
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dyscohesive cells w/ oval or round nuclei that lack the cell adhesion protein E-cadherin (expressed...
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gross features of invasive breast carcinoma
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firm or hard mass w/ small pinpoint foci or streaks of chalky white tissuemay have inverted...
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poor prognostic factors for infiltrating breast carcinomas
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tumor size > 2 cmlymph node involvementfixation to chest wallvascular or lymphatic involvementporr...
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causes of gynecomastia
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due to a hormonal imbalance of estrogen and androgen, which is often idiopathic in prepubertal...
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histologic features of gynecomastia
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stromal and ductular tissue increases in amt w/ hyperplasia of the ductal epithelium and often...
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