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Side A
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Side B
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| 1. |
What % of androgens are created by adrenal... |
10%. Androstenedione and dehydroepiandrosterone... |
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11. |
What is prolactin's effect on testosterone? |
Inhibits GnRH, and hence decreases testosterone. ... |
2. |
What effect do estrogens / progesterones... |
Decreases testicular production of testosterone. ... |
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12. |
How fast do you get castrate levels after... |
2-12 hours |
3. |
What is effect of estrogen on prolactin? |
Estrogens increase serum prolactin. |
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13. |
What are side effects of estrogen? |
Embolic, cardiac (MI), peripheral edema,... |
4. |
Do progesterones affect prolactin? |
No, compare to estrogen which does increase... |
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14. |
What are examples of progesterone and what... |
Megace. Initial decrease in testosterone,... |
5. |
What is role for prolactin antagonists in... |
Those that are no longer responsive to standard... |
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15. |
How long do LHRH agonists take to reach castrate... |
30 days. Can have flare phenomenon. ... |
6. |
What is problem and benefit of LHRH antagonists? |
Can cause cumulative risk of systemic allergic... |
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16. |
How does ketoconazole work? How long... |
inhibits cytrochrome p450. Reduces... |
7. |
What is affect of aminoglutethimide? |
Inhibits adrenal and testicle production... |
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17. |
What is affect on adrenal and gonadal androgen... |
They increase because receptors in pituitary... |
8. |
What are examples of nonsteroidal antiandrogens? |
Flutamide, biaclutamide, nilutamide. ... |
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18. |
What is mechanism of steroidal antiandrogens? |
Inhibits binding of DHT and testosterone... |
9. |
What is affect on prostate of androgen deprivation? |
Atrophy of glands. Decreased gland... |
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19. |
How long does flare last w/ LHRH agonists? |
Peaks at 3-4 days, lasts 7 days. |
10. |
How long in advance should you start the... |
4 half lives. Flutamide (32 hours). ... |
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20. |
What is antiandrogen withdrawal? |
Decline in PSA that occurs after stopping... |
