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Cards In This Set
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What are the two major groups of drugs used to treat psychosis?
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Neuroleptics and atypical antipsychotics
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Which of the above two groups has more extrapyramidal symptoms (EPS)?
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Neuroleptics (Haldol)
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What are the negative symptoms of schizophrenia?
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Negative symptoms include social and emotional withdrawal, lack of motivation, poor insight, judgement, and self-care, and poverty of speech.
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What are the positive symptoms of schizophrenia?
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Positive symptoms include hallucinations, delusions, disordered thinking, disorganized speech, combativeness, agitation and paranoia.
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What is the MOA of conventional antipsychotic drugs?
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Block dopamine receptors.
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How long does it take to reach a therapeutic response to antipsychotic drugs?
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Few months
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Conventional antipsychotic drugs have anticholinergic and what other kinds of side effects?
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Neuroendocrine and sexual dysfunction side effects.
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They can also lower blood pressure and cause_________.
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Sedation
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EPS
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Disrupts this function causing dyskinesias or abnormal movements
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Acute dystonia
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Spasms of the facial muscle
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Parkinsonism
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Tremor, bradyikinesia, cog-wheeling
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Tardive dyskinesia
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Involuntary, twisting movement of tongue and face
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Neuroleptic malignant syndrome
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“leadpipe” rigidity, sudden high fever, sweating, dysrhythmias
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Chlorpromazine (Thorazine) and haloperidol (Haldol) are examples of what type of antipsychotic agents?
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Conventional, also known as neuroleptics. Thorazine is low potency and Haldol is high potency.
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Give an example of an atypical antipsychotic agent.
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Clozapine
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