Before anything else, you should first understand what a TMF or a Trial Master File is. This is a set of important documents that will be referred to before the clinical trial will take place. This can also be used for evaluation purposes. There is not enough information available that will say who created this in the beginning.
This seems to be around ever since clinical practice has taken place. This used to be kept in various file cabinets but because of modern times, it can now be placed electronically in different computers and gadgets. A lot of countries support the use of TMF since this can make things clearer.
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